Results 61 to 70 of about 194,925 (268)

Fractional Vector Calculus and Fractional Maxwell's Equations

, 2011
The theory of derivatives and integrals of non-integer order goes back to Leibniz, Liouville, Grunwald, Letnikov and Riemann. The history of fractional vector calculus (FVC) has only 10 years. The main approaches to formulate a FVC, which are used in the
Belleguie, Ben Adda, Ben Adda, Ben Adda, Ben Adda, Brandt, Chen, Cottrill-Shepherd, Engheta, Foley, Gelfand, Genchev, Hussain, Hussain, Kazbekov, Kilbas, Kiryakova, Laskin, Mashhoon, Mashhoon, Mashhoon, McBride, Meerschaert, Metzler, Metzler, Miller, Montroll, Naqvi, Naqvi, Nishimoto, Oldham, Pierantozzi, Podlubny, Ross, Rubin, Samko, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Tarasov, Vasily E. Tarasov, West, Zaslavsky, Zaslavsky   +55 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

La dinámica interdisciplinar del proceso de enseñanza-aprendizaje del Cálculo Diferencial e Integral en la carrera Ingeniería Civil Model of the interdisciplinary dynamics of the teaching-learning process of Differential and Integral Calculus in the Civil Engineering career

Transformación, 2018
The current information society demands that civil engineers have an adequate command of the contents of Differential and Integral Calculus as a basis for their successful professional performance.
Nilda Iglesias Domecq, Isabel Alonso Berenguer, Alexander Gorina Sánchez   +2 more
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The definite integrals of 2- refined neutrosophic functions and its properties [PDF]

Neutrosophic Sets and Systems
This article aims to study the definite integrals of 2- refined neutrosophic functions and its properties. The definite integrals of 2- refined neutrosophic functions are defined in this study, and a set of theories are presented, including the ...
Yaser Ahmad Alhasan, Mohamed Elghazali Ali Mohieldin Mohamed, Raja Abdullah Abdulfatah   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Variations à la Fourier-Weyl-Wigner on Quantizations of the Plane and the Half-Plane

Entropy, 2018
Any quantization maps linearly function on a phase space to symmetric operators in a Hilbert space. Covariant integral quantization combines operator-valued measure with the symmetry group of the phase space.
Hervé Bergeron, Jean-Pierre Gazeau
doaj   +1 more source

Some new Hardy-type inequalities on time scales

Advances in Difference Equations, 2020
In this paper, we will prove some new dynamic inequalities of Hardy-type on time scales. Some of the integral and difference inequalities that will be derived from our results in the continuous and discrete cases are original.
Ahmed A. El-Deeb, Hamza A. Elsennary, Dumitru Baleanu   +2 more
doaj   +1 more source