Results 81 to 90 of about 27,845 (263)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

ON THE INTEGRAL CLOSURES OF IDEALS

open access: yesHonam Mathematical Journal, 2007
Let R be a commutative Noetherian ring (with a nonzero identity) and let M be an R-module. Further let I be an ideal of R. In this paper, by putting a suitable condition on (M), we obtain some results concerning and prove that the sequence of sets , , is increasing and ultimately constant. (Here denotes the integral closure of relative to M.)
H. Ansari-Toroghy, F. Dorostkar
openaire   +1 more source

A simple method to model crack propagation in concrete [PDF]

open access: yesConstructii: Journal of Civil Engineering Research, 2012
Crack analysis is vital to explain behavior of concrete structures. In the present study, an interface element with softening spring is used to simulate cohesive zone model (CZM) in beam to accurately explain the propagation for mixed-mode crack ...
Shahriar SHABAZPANAHI   +4 more
doaj  

Mixed-mode thermo elastic delamination fracture behavior of composite skin stiffener containing interface delamination

open access: yesJournal of Materials Research and Technology, 2019
This paper presents the thermo-elastic effect on materials having anisotropic behavior and stresses developed due to residual temperature on interlaminar delamination fracture characteristics of composite skin stiffener.
Saumya Shah   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Anisotropy and the integral closure

open access: yesJournal of Number Theory, 2014
Let K be a number field and let A be an order in K. The trace map from K to Q induces a non-degenerate symmetric bilinear form : B x B \to Q/Z where B is a certain finite abelian group of size Δ(A). In this article we discuss how one can obtain information about \mathcal{O}_K by purely looking at this symmetric bilinear form. The concepts of anisotropy
openaire   +3 more sources

Liftable integral closure

open access: yes, 2013
We develop the basic properties of an essentially new closure operation on submodules, the \emph{liftable integral closure} of a submodule, including its relationships with the two prevailing notions of integral closure of submodules. We show that for a quite general class of local rings, every finite length module may be represented as a quotient of ...
Epstein, Neil, Ulrich, Bernd
openaire   +2 more sources

Contrasted effects of temperate forest closure on snake demography

open access: yesEcosphere
Habitat modification is the main threat to biodiversity, but other causes are involved, such as climate change or pollution. To optimize conservation efforts, it is crucial to determine their respective contributions. An effective approach to disentangle
G. Billy, C. Barbraud, X. Bonnet
doaj   +1 more source

On certain classes of close-to-convex functions

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1993
A function f, analytic in the unit disk E and given by , f(z)=z+∑k=2∞anzk is said to be in the family Kn if and only if Dnf is close-to-convex, where Dnf=z(1−z)n+1∗f, n∈N0={0,1,2,…} and ∗ denotes the Hadamard product or convolution.
Khalida Inayat Noor
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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