Results 101 to 110 of about 679,276 (278)

Factorization in integral domains, II

Journal of Algebra, 1992
Les AA. continuent l'étude des propriétés des anneaux intègres, qui sont plus faibles que les propriétés de anneaux factoriels, commencé dans la première partie du papier [cf. J. Pure Appl. Algebra 69, No. 1, 1-19 (1990; Zbl 0727.13007)]. Dans cette deuxième partie sont étudiés les comportements des propriétés pour les extensions d'anneaux intègres ...
Anderson, D.D, Anderson, David F, Zafrullah, Muhammad   +2 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Conducive integral domains as pullbacks

Manuscripta Mathematica, 1986
A ''conducive domain'' is a (commutative unitary integral) domain R, with quotient field F, such that for every overring T of R, \(R\subseteq T\subsetneqq F\), the conductor \((R:T)=\{x\in F;\quad xT\subseteq R\}\) is nonzero [cf. \textit{E. Bastida} and \textit{R. Gilmer}, Mich. Math. J. 20, 79- 95 (1973; Zbl 0239.13001) and \textit{D. E.
BARUCCI, Valentina, D. Dobbs, M. Fontana
openaire   +4 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Integral Education and Fulltime Schools in Goiânia

Educação & Realidade, 2014
This article aims at identifying the school staff’s conceptions about integral education and fulltime schooling from a public school in Goiânia. It is a qualitative study based on ethnography in which the following instruments of generating data were ...
Helen Betane Ferreira, Dilys Karen Rees
doaj  

An Alternative Approach of Initial Stability Analysis of Kirchhoff Plates by the Boundary Element Method

Engineering Transactions, 2014
An initial stability of Kirchhoff plates is analysed in the paper. Proposed approach avoids Kirchhoff forces at the plate corner and equivalent shear forces at a plate boundary. Two unknown variables are considered at the boundary element node.
Michał GUMINIAK
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source