Results 111 to 120 of about 142,767 (307)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
On Generalized k-Uniformly Close-to-Convex Functions of Janowski Type
International Journal of Analysis and Applications, 2019 This work is concerned with the class of analytic functions that maps open unit disk onto conic domains. Necessary condition, arc length, growth rate of coefficients, radius problems and property of some integral transformation under the class are ...
Afis Saliu
doaj +2 more sources
Duality in Noetherian Integral Domains
Rocky Mountain Journal of Mathematics, 1999 Let \(A\) be a torsion-free abelian group of rank one and let \(C(A)\) denote the class of torsion-free abelian groups \(M\) of finite rank such that \(M\) embeds as \(\text{End}(A)\)-submodule of \(A^n\) for some \(n\). Then the map \(M\) to \(\Hom(M,A)\) on \(C(A)\) defines a duality. This is called Warfield duality. In this paper, the author gives a
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Fast Implementation of Generalized Koebe’s Iterative Method
MathematicsLet G be a given bounded multiply connected domain of connectivity m+1 bounded by smooth Jordan curves. Koebe’s iterative method is a classical method for computing the conformal mapping from the domain G onto a bounded multiply connected circular domain
Khiy Wei Lee +3 more
doaj +1 more source
An Essential Integral Domain with a Non-Essential Localization [PDF]
, 1981 William Heinzer
openalex +1 more source