Results 131 to 140 of about 2,185,451 (280)
AN OVERVIEW OF NUCLEAR MAGNETIC RESONANCE [PDF]
, 2014 There are a number of techniques available for investigating the structures of materials. One of the most powerful techniques capable of providing information both about the structure of materials and about the dynamics of process within those materials ...
Nicolas Gunawidjaja, Philips
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
DISTINGUISHING BETWEEN SCIENCE AND SCIENTISM [PDF]
, 2014 Issues of conflict between science and faith/religion have existed for a long time. Some of the topics that have become the source of the conflicts are: The Evolution Theory and The Big Bang Theory which are assumed to be in contra with the creation ...
Christin, Christin
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Localized direct segregated boundary-domain integral equations for variable-coefficient transmission problems with interface crack [PDF]
, 2011 The full text of the published article can be accessed at the link belowSome transmission problems for scalar second order elliptic partial differential equations are considered in a bounded composite domain consisting of adjacent anisotropic subdomains ...
Mikhailov, SE +2 more
core +1 more source
THE INFLUENCE OF LIFE EXPECTANCY IN THE DETERMINATION OF PENSION FUND INVESTMENTS [PDF]
, 2014 Preparating one’s retirement is important for many people, because an employee will often have no salary anymore after retiring, but his/her daily needs are still remained.
Kristiani, Farah
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
ANALISIS MODEL PROBABILISTIK PUNAHNYA MUTAN PARASIT MALARIA YANG RESISTEN TERHADAP KLOROKUIN PLUS AMODIAKUIN [PDF]
, 2014 In this paper probabilistic models are developed from a model of malaria parasite population dynamics proposed by Macdonald [1] based on Galton-Watson branching and generating Negative Binomial distribution with maximum likelihood estimation, to test a ...
Nainggolan, Jonner
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source