Results 41 to 50 of about 142,767 (307)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Parabolic Marcinkiewicz integrals on product spaces and extrapolation

open access: yesOpen Mathematics, 2016
In this paper, we study the the parabolic Marcinkiewicz integral MΩ,hρ1,ρ2${\cal M}_{\Omega, h}^{{\rho _{1,}}{\rho _2}}$ on product domains Rn × Rm (n, m ≥ 2). Lp estimates of such operators are obtained under weak conditions on the kernels.
Ali Mohammed, Al-Dolat Mohammed
doaj   +1 more source

On integrally dependent integral domains [PDF]

open access: yesPhilosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences, 1947
Abstract The subject of this paper is the simultaneous ideal theory of a pair of integral domains R and G ≥ R, of which R is integrally closed, and G integrally dependent on R. It is assumed that the quotient field L of G is a finite separable extension of the quotient field K of R.
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Almost Condensed Domains

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2013
As an extension of the class of half condensed domains introduced by D.D. Anderson and Dumitrescu, we introduce and study the class of almost condensed domains.
Khalid Waseem, Ur Rehman Shafiq
doaj   +1 more source

Overdetermined problems in annular domains with a spherical-boundary component in space forms

open access: yesJournal of Inequalities and Applications, 2023
We obtain a Serrin-type symmetry of the solutions to various overdetermined boundary value problems in annular domains with a spherical-boundary component in space forms by using the maximum principle for suitable subharmonic functions and integral ...
Jihye Lee, Keomkyo Seo
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

The Jump Problem for Mixed-Type Equations with Defects on the Type Change Line

open access: yesBoundary Value Problems, 2010
The jump problem and problems with defects on the type change line for model mixed-type equations in the mixed domains are investigated. The explicit solutions of the jump problem are obtained by the method of integral equations and by the Fourier ...
Ahmed Maher
doaj   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Fractal-fractional estimations of Bullen-type inequalities with applications

open access: yesAin Shams Engineering Journal
The study of inequalities inside fractal domains has been stimulated by the growing interest in fractional calculus for the applied and mathematical sciences.
Saad Ihsan Butt   +3 more
doaj   +1 more source

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