Results 151 to 160 of about 5,388,871 (377)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Numerical solution of singular integro-differential Prandtl equation by the method of orthogonal polynomials

open access: yesЖурнал Белорусского государственного университета: Математика, информатика, 2019
The paper is constructed and proved computational scheme for a solution of singular Prandtl of integro-differential  equations with singular integral over the interval of the real axis, understood in the sense of the Cauchy principal value.
Galina A. Rasolko
doaj  

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Integral solutions of fractional evolution equations with nondense domain

open access: yesElectronic Journal of Differential Equations, 2017
In this article, we study the existence of integral solutions for two classes of fractional order evolution equations with nondensely defined linear operators.
Haibo Gu   +3 more
doaj  

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

Integration of Stiff Equations [PDF]

open access: yesProceedings of the National Academy of Sciences, 1952
Curtiss, C. F., Hirschfelder, J. O.
openaire   +2 more sources

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

open access: yesFEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar   +3 more
wiley   +1 more source

An integral equation associated with P+2Fp+1

open access: yesRevista Técnica de la Facultad de Ingeniería, 2011
The solutión of an integral equation associated with a generalized hypergeometric polynomial p+2Fp+1 is obtained in terms of certain integral operators by the application of Rodrigues formula.
R. Saxena, S. Kalla
doaj  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

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