Results 101 to 110 of about 2,326,383 (287)

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Integral Transform Methods for Solving Fractional Dynamic Equations on Time Scales

Abstract and Applied Analysis, 2014
We introduce nabla type Laplace transform and Sumudu transform on general time scale. We investigate the properties and the applicability of these integral transforms and their efficiency in solving fractional dynamic equations on time scales.
Mohamad Rafi Segi Rahmat
doaj   +1 more source

New aspects of Opial-type integral inequalities

Advances in Difference Equations, 2018
In this manuscript, we prove new aspects for several Opial-type integral inequalities for the left and right Caputo–Fabrizio operators with nonsingular kernel. For this purpose we use the inequalities obtained by Andrić et al.
Yasemin Başcı, Dumitru Baleanu
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Localized boundary-domain integral equation formulation for mixed type problems [PDF]

, 2010
Copyright @ 2010 Walter de Gruyter GmbHSome modified direct localized boundary-domain integral equations (LBDIEs) systems associated with the mixed boundary value problem (BVP) for a scalar “Laplace” PDE with variable coefficient are formulated and ...
Mikhailov, SE, Natroshvili, D, Chkadua, O, David Natroshvili, Sergey E. Mikhailov, Otar Chkadua   +5 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

HYBRIDIZATION OF SHEHU TRANSFORM AND VARIATIONAL ITERATION METHOD FOR SOLUTION OF FRACTIONAL ORDER PARTIAL VOLTERRA INTEGRO-DIFFERENTIAL EQUATIONS

Academy Journal of Science and Engineering
This paper presents a method of solution to a class of fractional order Volterra integro-   differential equations which are at the same time nonlinear. To effectively model some physical phenomena in mathematical physics, both integral and differential ...
Babatunde Morufu Yisa, Muhammed Olayemi Osayemi   +1 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source