Results 101 to 110 of about 181,927 (288)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Khalouta transform and applications to Caputo-fractional differential equations

Frontiers in Applied Mathematics and Statistics
The paper aims to utilize an integral transform, specifically the Khalouta transform, an abstraction of various integral transforms, to address fractional differential equations using both Riemann-Liouville and Caputo fractional derivative.
Nikita Kumawat, Akanksha Shukla, Manvendra Narayan Mishra, Rahul Sharma, Ravi Shanker Dubey   +4 more
doaj   +1 more source

Calculating multivariate ruin probabilities via Gaver–Stehfest inversion technique. [PDF]

Multivariate characteristics of risk processes are of high interest to academic actuaries. In such models, the probability of ruin is obtained not only by considering initial reserves u but also the severity of ruin y and the surplus before ruin x.
Usábel, Miguel A.
core  

Применения обобщенных интегральных преобразований [PDF]

, 2015
Проблематика. Статтю присвячено дослідженню узагальнених інтегральних перетворень, а саме узагальненого інтегрального перетворення Лапласа, узагальненого інтегрального перетворення Стільтьєса. Мета дослідження.
Chetvertak, M. O., Virchenko, N. O., Вирченко, Н. А., Вірченко, Ніна Опанасівна, Четвертак, М. А., Четвертак, Марія Олександрівна   +5 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

APPLICATION OF INTEGRAL TRANSFORMS TO SOLVING LINEAR EQUATIONS

Demonstratio Mathematica, 1985
The paper includes an effective complex-analytical procedure for obtaining solutions of nth order linear differential equation \(\sum^{n}_{k=0}a_{k+1}(t)x^{(k)}(t)=z(t)\) with given \(x^{(k)}(0)\), \(k=0,1,...,n-1\). Functions \(a_{k+1}(t)\), \(t\geq 0\), \(k=0,1,...,n\), are piecewise continuously differentiable up to order n, while z(t) is for \(t ...
openaire   +2 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Polyconvolution and the Toeplitz plus Hankel integral equation

Electronic Journal of Differential Equations, 2014
In this article we introduce a polyconvolution which related to the Hartley and Fourier cosine transforms. We prove some properties of this polyconvolution, and then solve a class of Toeplitz plus Hankel integral equations and systems of two ...
Nguyen Xuan Thao, Nguyen Minh Khoa, Phi Thi Van Anh   +2 more
doaj  

Comparison of Complex Sadik and KAJ Transforms for Ordinary Differential Equations to the Response of an Uncompressed Forced Oscillator

Ibn Al-Haitham Journal for Pure and Applied Sciences
In this paper we have presented a comparison between two novel integral transformations that are of great importance in the solution of differential equations. These two transformations are the complex Sadik transform and the KAJ transform.
Saed M. Turq, Emad A. Kuffi
doaj   +1 more source

New aspects of Opial-type integral inequalities

Advances in Difference Equations, 2018
In this manuscript, we prove new aspects for several Opial-type integral inequalities for the left and right Caputo–Fabrizio operators with nonsingular kernel. For this purpose we use the inequalities obtained by Andrić et al.
Yasemin Başcı, Dumitru Baleanu
doaj   +1 more source