The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Khalouta transform and applications to Caputo-fractional differential equations
The paper aims to utilize an integral transform, specifically the Khalouta transform, an abstraction of various integral transforms, to address fractional differential equations using both Riemann-Liouville and Caputo fractional derivative.
Nikita Kumawat +4 more
doaj +1 more source
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Polyconvolution and the Toeplitz plus Hankel integral equation
In this article we introduce a polyconvolution which related to the Hartley and Fourier cosine transforms. We prove some properties of this polyconvolution, and then solve a class of Toeplitz plus Hankel integral equations and systems of two ...
Nguyen Xuan Thao +2 more
doaj
In this paper we have presented a comparison between two novel integral transformations that are of great importance in the solution of differential equations. These two transformations are the complex Sadik transform and the KAJ transform.
Saed M. Turq, Emad A. Kuffi
doaj +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Mesh-based numerical implementation of the localized boundary-domain integral equation method to a variable-coefficient Neumann problem [PDF]
An implementation of the localized boundary-domain integral-equation (LBDIE) method for the numerical solution of the Neumann boundary-value problem for a second-order linear elliptic PDE with variable coefficient is discussed.
Mikhailov, SE, Nakhova, IS
core +3 more sources
Cutting-Edge Spectral Solutions for Differential and Integral Equations Utilizing Legendre’s Derivatives [PDF]
This research introduces a spectral numerical method for solving some types of integral equations, which is the pseudo-Galerkin spectral method. The presented method depends on Legendre’s first derivative polynomials as basis functions.
A.M. Abbas +3 more
doaj +1 more source

