Results 71 to 80 of about 5,317 (265)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

MULTIPLE FOURIER SERIES AND FOURIER INTEGRALS WITH NON-SEPARABLE VARIABLES

Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2020
Background. Integral transforms for functions of several variables are an actively developing area of mathematical analysis. Numerous applications in integral transforms method for solving equations of mathematical physics, in signal processing of ...
O. E. Yaremko, N. N. Yaremko, E. S. Mogileva   +2 more
doaj   +1 more source

Generalization to The AMK Integral Transform and Its Applications [PDF]

مجلة جامعة الانبار للعلوم الصرفة
Since the proposal of Laplace to integral transformation in 1780, many integral transformations have been proposed. Some are based on Laplace, and others are totally independent.
Mohanad Salman, Qin Zhao
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Khalouta transform and applications to Caputo-fractional differential equations

Frontiers in Applied Mathematics and Statistics
The paper aims to utilize an integral transform, specifically the Khalouta transform, an abstraction of various integral transforms, to address fractional differential equations using both Riemann-Liouville and Caputo fractional derivative.
Nikita Kumawat, Akanksha Shukla, Manvendra Narayan Mishra, Rahul Sharma, Ravi Shanker Dubey   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Cutting-Edge Spectral Solutions for Differential and Integral Equations Utilizing Legendre’s Derivatives [PDF]

Iranian Journal of Numerical Analysis and Optimization
This research introduces a spectral numerical method for solving some types of integral equations, which is the pseudo-Galerkin spectral method. The presented method depends on Legendre’s first derivative polynomials as basis functions.
A.M. Abbas, Y.H. Youssri, M. El-Kady, M. Abdelhakem   +3 more
doaj   +1 more source

APPLICATION OF INTEGRAL TRANSFORMS TO SOLVING LINEAR EQUATIONS

Demonstratio Mathematica, 1985
The paper includes an effective complex-analytical procedure for obtaining solutions of nth order linear differential equation \(\sum^{n}_{k=0}a_{k+1}(t)x^{(k)}(t)=z(t)\) with given \(x^{(k)}(0)\), \(k=0,1,...,n-1\). Functions \(a_{k+1}(t)\), \(t\geq 0\), \(k=0,1,...,n\), are piecewise continuously differentiable up to order n, while z(t) is for \(t ...
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source