Results 61 to 70 of about 3,163 (263)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Existence theorems for completely non convex problems

Le Matematiche, 1986
In this note we give some existence theorems for integral functionals with non convex integrand. We consider first the simpler case in which minimization is taken on decomposable spaces and successively we prove an existence theorem also for the minimum ...
Ottavio Caligaris
doaj  

Spatio-temporal tensor-network approaches to out-of-equilibrium dynamics bridging open and closed systems

Frontiers in Quantum Science and Technology
The study of many-body quantum systems out of equilibrium remains a significant challenge, with complexity barriers arising in both state- and operator-based representations.
Sergio Cerezo-Roquebrún, Aleix Bou-Comas, Jan T. Schneider, Esperanza López, Luca Tagliacozzo, Stefano Carignano   +5 more
doaj   +1 more source

Naturally integrable functions [PDF]

Pacific Journal of Mathematics, 1980
Dubins, Lester E., Margolies, David
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Analysis of variational inequalities with fractional curvilinear integral functionals

Results in Applied Mathematics
This study examines weak sharp solutions for a category of variational inequalities incorporating functionals based on fractional curvilinear integrals, expanding the conventional approach with concepts from fractional calculus. Furthermore, by using the
Octavian Postavaru, Antonela Toma, Savin Treanţă   +2 more
doaj   +1 more source

Accuracy of discrete approximation for integral functionals of Markov processes

Modern Stochastics: Theory and Applications, 2015
The article is devoted to the estimation of the convergence rate of integral functionals of a Markov process. Under the assumption that the given Markov process admits a transition probability density differentiable in t and the derivative has an ...
Iurii Ganychenko, Victoria Knopova, Alexei Kulik   +2 more
doaj   +1 more source

On Functions of Integrals [PDF]

Proceedings of the Edinburgh Mathematical Society, 1932
The object of this paper is to discuss conditions for a maximum or minimum of functions of integrals of the typeemploying the methods of the Calculus of Variations.
openaire   +2 more sources