Results 101 to 110 of about 1,660,374 (285)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Two $$\beta $$ β -ensemble realization of $$\beta $$ β -deformed WLZZ models

European Physical Journal C: Particles and Fields
We consider a two $$\beta $$ β -ensemble realization of the series of $$\beta $$ β -deformed WLZZ matrix models. We demonstrate that such a realization involves $$\beta $$ β -deformed Harish-Chandra–Itzykson–Zuber integrals, one of them providing a ...
A. Mironov, A. Oreshina, A. Popolitov
doaj   +1 more source

The processes of identity integration

Filozofija i drustvo, 2009
Despite inevitable elusiveness of its meanings, explication of the persisting issues of identity remains the challenge for contemporary humans. Inability to achieve full insight into its complexity points to the need to corelate basic ideas as the essential way of self-cognition and self-awareness, which represent the meaning, value and the purpose of ...
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Integral identities for rational series involving binomial coeefficients

, 2011
We establish integral identities for series involving binomial coefficients. Using the identities, in some cases, we demonstrate they may be represented in closed form of rational type.
Husna Zayadi
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Triple integral identities . . .

, 2010
Some new identities are given for the representation of binomial sums. A master theorem is developed from which integral and closed form results, in terms of Zeta functions and harmonic numbers, are developed for sums of the type n≥1 t n n 4 an + j j bn +
Anthony Sofo
core  

Identity in the difference and integration in gender identity

Santiago, 2016
It is offered a synthesis of the vision of the poststructuralist feminism from some of their representatives. That tendence inquires the own cathegory of gender identity; as an alternative to the discussion, it is propoused the identity in the diference and the cultural integration in its condition of principles of complex identities.
Marybexy Calcerrada-Gutiérrez, Bárbara Martínez-Pupo   +1 more
openaire   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source