Results 81 to 90 of about 1,660,374 (285)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

On generalization of integral inequalities for strongly Φ-convex functions using Riemann-Liouville operators

Boundary Value Problems
This article introduces novel integral identities and results, with a particular focus on strongly Φ-convex functions and their associated inequalities. By leveraging Riemann-Liouville (RL) fractional integral operators, we first define strongly Φ-convex
Muhammad Sadaqat Talha, Waseem Razzaq, Abdulrahman Alomair, Abdulaziz S. Al Naim   +3 more
doaj   +1 more source

Some Identities of Symmetry for the Generalized Bernoulli Numbers and Polynomials

Abstract and Applied Analysis, 2009
By the properties of p-adic invariant integral on ℤp, we establish various identities concerning the generalized Bernoulli numbers and polynomials. From the symmetric properties of p-adic invariant integral on ℤp, we give some interesting relationship ...
Taekyun Kim, Seog-Hoon Rim, Byungje Lee
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identities Involving q-Bernoulli and q-Euler Numbers

Abstract and Applied Analysis, 2012
We give some identities on the q-Bernoulli and q-Euler numbers by using p-adic integral equations on ℤp.
D. S. Kim, T. Kim, J. Choi, Y. H. Kim
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Some Simpson- and Ostrowski-Type Integral Inequalities for Generalized Convex Functions in Multiplicative Calculus with Their Computational Analysis

Mathematics
Integral inequalities are very useful in finding the error bounds for numerical integration formulas. In this paper, we prove some multiplicative integral inequalities for first-time differentiable s-convex functions.
Xinlin Zhan, Abdul Mateen, Muhammad Toseef, Muhammad Aamir Ali   +3 more
doaj   +1 more source

Some Properties on the q-Euler Numbers and Polynomials

Abstract and Applied Analysis, 2012
We give some new identities on q-Euler numbers and polynomials by using the fermionic p-adic integral on ℤp.
T. Kim, S.-H. Lee
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source