Results 121 to 130 of about 537,045 (330)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

New local fractional Hermite-Hadamard-type and Ostrowski-type inequalities with generalized Mittag-Leffler kernel for generalized h-preinvex functions

Demonstratio Mathematica
In this study, based on two new local fractional integral operators involving generalized Mittag-Leffler kernel, Hermite-Hadamard inequality about these two integral operators for generalized hh-preinvex functions is obtained.
Sun Wenbing, Wan Haiyang
doaj   +1 more source

Optimal regularity of Fourier integral operators with one-sided folds [PDF]

, 2006
Andrew Comech
openalex   +1 more source

Unbounded Integral Hankel Operators

Functional Analysis and Its Applications
For a wide class of unbounded integral Hankel operators on the positive half-line, we prove essential self-adjointness on the set of smooth compactly supported functions.
Pushnitski, Alexander, Treil, Sergei
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Boundedness for a Class of Singular Integral Operators on Both Classical and Product Hardy Spaces

Abstract and Applied Analysis, 2014
We found that the classical Calderón-Zygmund singular integral operators are bounded on both the classical Hardy spaces and the product Hardy spaces. The purpose of this paper is to extend this result to a more general class. More precisely, we introduce
Chaoqiang Tan
doaj   +1 more source

An Integral Operator Solution to the Matrix Toda Equations [PDF]

, 1997
Harold Widom
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An interpolation theorem related to the a.e. convergence of integral operators [PDF]

, 1996
Alexander Kiselev
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source