Results 71 to 80 of about 7,950,423 (253)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Polynomiality of method for computing graph structure integral descriptor
, 2013 Актуальность исследования определяется большой потребностью в разработке эффективных методов инвариантного описания и анализа абстрактных структур графовых моделей.
Погребной, Владимир Кириллович +1 more
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Volterra integral equations and fractional calculus: Do neighbouring solutions intersect? [PDF]
, 2012 This is the author's PDF version of an article published in Journal of Integral Equations and Applications. The definitive version is available at rmmc.asu.edu/jie/jie.html.This journal article considers the question of whether or not the solutions to ...
Diethelm, Kai, Ford, Neville J.
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Abstract This study presents a unified descriptor-based QSAR framework for analyzing pesticide mixtures from the dual perspective of antifungal efficacy and honey bee toxicity. Rather than developing independent predictive models optimized for individual endpoints, the framework is designed to enable cross-endpoint ...
Chia Ming Chang, Tien-Cheng Liu
openaire +1 more source
Descriptor system techniques in solving H2/infinity-optimal fault detection and isolation problems [PDF]
, 2012 This chapter illustrates the effectiveness of descriptor systems based algorithms in solving H2/infinity-optimal fault detection and isolation problems.
Varga, Andreas
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