Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Household behavior change for climate change response: an integral scan [PDF]
, 2009 The question of how to successfully facilitate the changes needed to avoid dangerous climate change has become a critical one for researchers and practitioners.
Riedy, C
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Fail-safe design of integral metallic aircraft structures reinforced by bonded crack retarders [PDF]
, 2009 This paper presents an investigation on the effectiveness of crack growth retarders bonded to integral metallic structures. The study was performed by both numerical modelling and experimental tests.
Irving, Phil E. +9 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Descriptor system techniques in solving H2/H-infinity optimal fault detection and isolation problems. [PDF]
, 2012 This chapter illustrates the effectiveness of descriptor systems based algorithms in solving H2/H-infinity optimal fault detection and isolation problems.
Varga, A
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Integral group ring of the McLaughlin simple group [PDF]
, 2007 We consider the Zassenhaus conjecture for the normalized unit group of the integral group ring of the McLaughlin sporadic group McL.
Bódi, Viktor +3 more
core +1 more source
Torsion units in integral group ring of the Mathieu simple group M22 [PDF]
, 2008 We investigate the possible character values of torsion units of the normalized unit group of the integral group ring of the Mathieu sporadic group M22.
Bódi, Viktor +6 more
core +1 more source