Results 71 to 80 of about 4,172 (287)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Certain Integral Transforms for the Incomplete Functions [PDF]

, 2015
Srivastava et al. [14] introduced the incomplete Pochhammer symbols that lead to a natural generalization and decomposition of a class of hypergeometric and other related functions to mainly investigate certain potentially useful closed-form ...
Agarwal, Praveen, Choi, Junesang
core   +1 more source

On Symmetrical Sonin Kernels in Terms of Hypergeometric-Type Functions

Mathematics
In this paper, a new class of kernels of integral transforms of the Laplace convolution type that we named symmetrical Sonin kernels is introduced and investigated.
Yuri Luchko
doaj   +1 more source

Analysis of a Normalized Structure of a Complex Fractal–Fractional Integral Transform Using Special Functions

Axioms
By using the most generalized gamma function (parametric gamma function, or p-gamma function), we present the most generalized Rabotnov function, called the p-Rabotnov function. Consequently, new fractal–fractional differential and integral operators of a complex variable in an open unit disk are defined and investigated analytically and geometrically.
Rabha W. Ibrahim, Soheil Salahshour, Ágnes Orsolya Páll-Szabó   +2 more
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

On the $(k,\psi )$-Generalized Laplace Transforms and Their Applications to Fractional Differential Equations

Communications in Advanced Mathematical Sciences
In this paper, a new generalization of the Laplace transform, called the $(k,\psi )$-generalized Laplace transform, which plays an important role in solving many problem models, is introduced and its special properties are given.
Emine Cengizhan, Yasemin Başcı, Adil Mısır   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Stress analysis of thin and thick plates on elastic foundations using boundary and finite element methods [PDF]

, 1991
In this work an attempt has been made to derive a full finite element and boundary element theory for the analysis of thin and thick plates on elastic foundations. A new high order shear finite element capable of the analysis of thin thick plates has
Al-Hosani, Khaleel Ibrahim Abdulla
core