Results 111 to 120 of about 707 (206)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Região, etnicidade e política: o integralismo e as lutas pelo poder político no Sul Catarinense na década de 1930 [PDF]
, 2007 Essa tese ao fazer um estudo do Integralismo buscou compreender as lutas pelo poder político em Santa Catarina e em particular no Sul Catarinense na década de 1930.
Zanelatto, João Henrique
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Varia História, 2012 O objetivo do trabalho é analisar a atuação da Ação Integralista Brasileira (AIB) na construção da sua galeria de mártires políticos. Esse partido surgiu a partir da unificação de inúmeros movimentos e organizações que se fundiram em 1932 e configurou-se
Pedro Ernesto Fagundes
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Anuario de la Escuela de Historia Virtual, 2012 El siguiente trabajo pretende analizar la publicación Norte Argentino, editada en Tucumán desde principios de 1942, cuya línea editorial era guiada por militantes de la Acción Católica de la provincia.
Piliponsky, Esteban
doaj
Biochemical systems analysis of signaling pathways to understand fungal pathogenicity. [PDF]
Methods Mol Biol, 2011 Garcia J +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source