Results 101 to 110 of about 561 (262)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Fotografias do Integralismo para além do Integralismo: breves análises e propostas
, 2021 The aim of this paper is to analyze several types of photography in the Integralist magazine Anauê! taking into account their cultural and social aspects.
Ramos, Alexandre Pinheiro
core
A Primer on Integral Theory and Its Application to Mental Health Care. [PDF]
Glob Adv Health Med, 2020 Duffy JD.
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Journal of Moral TheologyThe influential writings on church and state of philosopher Jacques Maritain, who died in 1973, possessed a mid-twentieth century hopefulness about a new birth of freedom and a lay-led Christian humanism.
Brian J. A. Boyd
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The German Controversy over Integralism and the Making of the Encyclical "Singulari quadam"
On the basis of extensive unpublished documentation, the contribution reconstructs the position of the Holy See regarding the "Controversy over Integralism" which characterised German Catholicism during the pontificate of Pius X.
Francesco Tacchi
core
Social SciencesIn the contemporary epistemological debate, it is possible to identify approaches whereby rational and sensory human faculties are not the sole essential dimensions in the knowing process.
Licia Paglione
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source