Results 51 to 60 of about 707 (206)

O sigma na atualidade [PDF]

open access: yes, 2021
Brazilian Integralism had its heyday in the 1930s when the Brazilian Integralist Action (AIB) party was organized nationally, bringing together a militancy that embraced, body and soul, its political proposal.
Carneiro, Márcia Regina da Silva Ramos
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

SISTEMATIZAREA INTEGRALISMULUI ȘI RESISTEMATIZAREA ȘTIINȚEI. CONTEXTUALIZAREA TRANSDISCIPLINARĂ (EPISTEMOLOGICĂ) A INTEGRALISMULUI LINGVISTIC*

open access: yesStudia Universitatis Moldaviae: Stiinte Umanistice, 2021
Pentru a extinde impactul coșerianismului asupra întregii culturi/celorlalte domenii ale cunoașterii, este esențială implicarea Transdisciplinarității în studiul Lingvisticii Integrale. Lucrarea propune o privire transdisciplinară asupra modului în care
USM ADMIN
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

A Segretaria Nazionale dei fasci all´estero, a NSDAP-Auslandsorganisation, o servicio exterior de la falange e as políticas externas dos partidos fascistas no entre-guerras. O caso latino-americano

open access: yesNuevo mundo - Mundos Nuevos, 2017
In the period between the two world wars, many parties and fascist movements had its own foreign policy, embodied in party institutions as the fasci all'estero, the NSDAP-AO, the Servicio Exterior de la Falange and others.These organizations had as a ...
João Fábio Bertonha
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Estado Forte em combate ao Liberalismo: o projeto antissemita integralista de Gustavo Barroso para o Brasil dos anos 1930; Estado fuerte en combate al liberalismo: el proyecto antisemita integralista de Gustavo Barroso para el Brasil de los años 1930; Strong State in the fight against Liberalism: the integralist anti-Semitic project of Gustavo Barroso for Brazil in the 1930s

open access: yesRevista nuestrAmérica, 2019
Resumo: O projeto integralista almejado por Gustavo Barroso baseava-se no modelo de Estado forte. Diferente da postura de Plínio Salgado e Miguel Reale, que não carregavam o racismo contra a figura do judeu, Barroso pensa a formação do novo Brasil com a ...
Cicero João da Costa Filho
doaj  

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