Results 71 to 80 of about 707 (206)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
On the epistemology of postmodern spirituality
Verbum et Ecclesia, 2012 At first glance, the postmodern spiritual scene appears sociologically messy, experiential, multifaceted, ecological, provisional and collective (Petrolle 2007) and of uncertain epistemic provenance.
Dudley A. Schreiber
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Catholic fundamentalism: towards a discussion of the phenomenon and the application of the term [PDF]
Вестник Православного Свято-Тихоновского гуманитарного университета: Серия I. Богословие, философияThe article is devoted to the topic of catholic fundamentalism, which is not sufficiently highlighted in Russian church-historical science. It aims to update the discussion on the possibility of the religious phenomenon Catholic Fundamentalism, as well ...
Dmitriy Golovushkin
doaj +1 more source
Credibility Enhancing Displays, religious scandal and the decline of Irish Catholic orthodoxy. [PDF]
Evol Hum Sci, 2022 Turpin HD, Willard AK.
europepmc +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
The initial discourses of (neo?)integralism: in-depth analysis of a speech by Plínio Salgado in 1961
, 2023 With almost a hundred years within the Brazilian public debate, Integralism went through several stages and cycles, changing internally according to its time.
Schargel, Sergio
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source