Results 71 to 80 of about 85,046 (318)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Feynman integrals, hypergeometric functions and nested sums

open access: yes, 2009
Bejdakic E. Feynman integrals, hypergeometric functions and nested sums. Bielefeld (Germany): Bielefeld University; 2009.In this thesis, we present analytical expansion results of some single-mass-scale four-loop vacuum integrals in 3 and 4 dimensions ...
Bejdakic, Ervin
core  

Hyperelliptic Integrals to Elliptic Integrals

open access: yesProceedings of the 2023 International Symposium on Symbolic and Algebraic Computation, 2023
Consider a hyperelliptic integral $I=\int P/(Q\sqrt{S}) dx$, $P,Q,S\in\mathbb{K}[x]$, with $[\mathbb{K}:\mathbb{Q}]<\infty$. When $S$ is of degree $\leq 4$, such integral can be calculated in terms of elementary functions and elliptic integrals of three kinds $\mathcal{F},\mathcal{E},Π$.
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Numerical methods of computation of singular and hypersingular integrals

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2001
In solving numerous problems in mathematics, mechanics, physics, and technology one is faced with necessity of calculating different singular integrals. In analytical form calculation of singular integrals is possible only in unusual cases.
I. V. Boikov
doaj   +1 more source

Derivation of functional equations for Feynman integrals from algebraic relations

open access: yesJournal of High Energy Physics, 2017
New methods for obtaining functional equations for Feynman integrals are presented. The application of these methods to finding functional equations for various one- and two-loop integrals is described in detail.
O. V. Tarasov
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Numerical quadrature methods for singular and nearly singular integrals

open access: yes, 2001
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis is concerned with the development, design, and analysis of simple and efficient numerical quadrature methods for integrals on finite intervals ...
Chunrungsikul, S.   +1 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

A General Ostrowski Type Inequality for Double Integrals

open access: yes, 2000
Some generalisations of an Ostrowski Type Inequality in two dimensions for n-time differentiable mappings are given. The result is an Integral Inequality with bounded n-time derivatives.
Hanna, George T   +2 more
core  

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