Anti-HIV-1 Activity of the Integrase Strand Transfer Inhibitor ACC017 [PDF]
VirusesHIV-1 integrase strand transfer inhibitors (INSTIs) are pivotal to antiretroviral therapy. However, the emergence of drug-resistant mutations necessitates the development of new agents. Here, we present ACC017 as a novel INSTI candidate.
Meng-Di Ma +8 more
doaj +6 more sources
META-INSTI: metabolic adverse events following integrase strand transfer inhibitor administration in spontaneous adverse event reports [PDF]
Drugs in Context, 2023 Background: Metabolic effects of integrase strand transfer inhibitors (INSTIs) have been reported. The FDA Adverse Event Reporting System (FAERS) is a publicly available database that captures spontaneously reported adverse events.
Milena M Murray +2 more
doaj +3 more sources
Cabotegravir, the Long-Acting Integrase Strand Transfer Inhibitor, Potently Inhibits Human T-Cell Lymphotropic Virus Type 1 Transmission in vitro [PDF]
Frontiers in Medicine, 2022 Human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus most prevalent in southwestern Japan, sub-Saharan Africa, Australia, South America, and the Caribbean. Latest figures approximate 10 million people worldwide to be infected with HTLV-1.
Bethany S. Schneiderman +2 more
doaj +3 more sources
Pretreatment integrase strand transfer inhibitor resistance in Tianjin, China [PDF]
Chinese Medical Journal, 2023 Huan Xia +5 more
doaj +4 more sources
Integrase Strand Transfer Inhibitor Resistance in Integrase Strand Transfer Inhibitor-Naive Persons [PDF]
AIDS Research and Human Retroviruses, 2021 There has been no systematic review of the prevalence of transmitted integrase strand transfer inhibitor (INSTI) resistance. We systematically searched the English-language PubMed database and GenBank to identify studies published since 2010 reporting 50 or more INSTI-naive HIV-1-infected adults undergoing integrase genotyping.
Soo-Yon Rhee, Robert W. Shafer
exaly +4 more sources
Incidence of cardiometabolic outcomes among people living with HIV‐1 initiated on integrase strand transfer inhibitor versus non‐integrase strand transfer inhibitor antiretroviral therapies: a retrospective analysis of insurance claims in the United States [PDF]
Journal of the International AIDS Society, 2023 Introduction Integrase strand transfer inhibitor (INSTI)‐containing antiretroviral therapy (ART) has been associated with weight gain, though there is limited information on associations between ART‐related weight gain and cardiometabolic outcomes among ...
Peter F. Rebeiro +7 more
doaj +2 more sources
Low level of HIV-1C integrase strand transfer inhibitor resistance mutations among recently diagnosed ART-naive Ethiopians [PDF]
Scientific Reports, 2023 With the widespread use of Integrase strand transfer inhibitors (INSTIs), surveillance of HIV-1 pretreatment drug resistance is critical in optimizing antiretroviral treatment efficacy.
Mulugeta Kiros +11 more
doaj +2 more sources
Prevalence and analysis of acquired and transmitted integrase strand transfer inhibitor-associated HIV-1 drug resistance in Chongqing, China [PDF]
Virulence, 2023 Huizheng Zhang, Jungang Li
exaly +2 more sources
VirusesRetroviruses perpetuate their survival by incorporating a copy of their genome into the host cell, a critical step catalyzed by the virally encoded integrase.
Irene Wanjiru Kiarie +6 more
doaj +3 more sources
One in 10 Virally Suppressed Persons With HIV in The Netherlands Experiences ≥10% Weight Gain After Switching to Tenofovir Alafenamide and/or Integrase Strand Transfer Inhibitor. [PDF]
Open Forum Infectious Diseases, 2022 Peter Reiss +2 more
exaly +2 more sources