Results 111 to 120 of about 2,882,240 (203)

Semaglutide improves MASLD and MASH in people with HIV: The SLIM LIVER study

HIV Medicine, Volume 27, Issue 10, Page 1710-1714, October 2026.
Abstract Objectives We have shown that semaglutide, a glucagon‐like peptide‐1 receptor agonist (GLP‐1RA), is a highly effective therapy for metabolic dysfunction‐associated steatotic liver disease (MASLD) in people with HIV (PWH). The OWLiver® metabolomics algorithms allow non‐invasive MASLD severity staging without liver biopsy, but the use of ...
Jordan E. Lake, Douglas W. Kitch, Amy Kantor, Rebeca Mayo, Pablo Belaunzaran‐Zamudio, Carl J. Fichtenbaum, Todd T. Brown, Kathleen E. Corey, Fred Sattler, Kristine M. Erlandson   +9 more
wiley   +1 more source

HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana

, 2021
There are limited real-world mutational and virological outcomes data of treatment-experienced persons diagnosed with HIV-1 subtype C (HIV-1 C) who are failing Integrase Strand Transfer Inhibitor-based regimens. Requisition forms sent for HIV-1 genotypic
Max Kapanda, Shahin Lockman, Madisa Mine, Mompati Mogwele, Mompati Mmalane, Nametso Mathiba, Wonderful T. Choga, Dinah Ramaabya, Joseph Makhema, Ishmael Kasvosve, Tshenolo Ntsipe, Dorcas Maruapula, Bornapate Nkomo, Sikhulile Moyo, Kaelo K. Seatla, Simani Gaseitsiwe   +15 more
core   +1 more source

Frailty and associated clinical factors among Japanese people with HIV: A multicentre cross‐sectional study using the revised Japanese Cardiovascular Health Study criteria

HIV Medicine, Volume 27, Issue 10, Page 1670-1681, October 2026.
Abstract Objectives Frailty is relevant to HIV care across middle and later life, yet Japanese data remain limited. We evaluated frailty, prefrailty and associated factors in Japanese people with HIV using the revised Japanese Cardiovascular Health Study (J‐CHS) criteria.
Hideta Nakamura, Julian Falutz, Taro Naka, Sho Miyamori, Nanae Ikemiyagi, Kazutaka Yamaniha, Shuhei Ideguchi, Rumi Minami, Masashi Narita, Michinori Shirano, Sei Samukawa, Tomoyuki Endo, Junji Imamura, Mayumi Imahashi, Shinichiro Ueda, Kazuko Yamamoto   +15 more
wiley   +1 more source

Durability of first-line regimens including integrase strand transfer inhibitors (INSTIs): data from a real-life setting

, 2020
To evaluate the durability of three integrase strand transfer inhibitors (INSTIs) and two NRTIs in ART-naive ...
Antinori Andrea, Lo Caputo, Sergio, Marchetti GC, Cingolani A, Gianotti N, Cinque P, Iardino R, Rusconi S, Bandera A, Quiros Roldan E, Girardi E, Maggiolo F, Galli M, Costantini, Andrea, De Luca A, Rezza G, Andreoni M, Di Perri G, Puoti M, Madeddu G, Gianotti, Nicola, von Schloesser F, Sarmati L, Marchetti, Giulia, Guaraldi G, Castelli F, Perno CF, Borderi M, Santoro MM, Rossotti R, Mazzotta, Valentina, Cauda R, Pinnetti C, Cozzi-Lepri, Alessandro, Capobianchi MR, Ceccherini-Silberstein F, Marchetti G, Castagna, Antonella, Lazzarin A, Saracino A, Capetti A, Antinori A, Nozza S, Di Biagio, Antonio, Cozzi-Lepri A, Viale P, Gori A, Castagna A, d'Arminio Monforte, Antonella, Rusconi, Stefano, Di Biagio A, Ippolito G, d'Arminio Monforte A, Mazzarello, Giovanni, Calcagno A, Cicalini S, Lapadula G, Lo Caputo S, Monno L, Bonora S, Balotta C, Mussini C, Lichtner M   +62 more
core   +1 more source

Real-world prevalence of integrase inhibitor resistance and virological failure since adoption as guideline-preferred therapy

Background: Limited data reporting real-world prevalence of integrase strand transfer inhibitor resistance (INSTI-R) in the USA are available because their recommendation as first-line treatment in 2017.
Emily Drwiega, Renata Smith, Melissa Badowski, Rodrigo Burgos, Jenna Januszka   +4 more
core   +1 more source

Brief communication: characteristics of primary drug resistance in newly diagnosed HIV-infected individuals in Ganzhou, China

AIDS Research and Therapy
Background Primary drug resistance (PDR) is an important cause of antiretroviral therapy (ART) failure. However, the prevalence and characteristics of PDR in Ganzhou remain unclear.
Dan-Dan Huang, Jun-Jie Liu, Ya-Ting Chen, Rong-Rong Yang, Jun-Zhi Su, Qian Gao, Xin Chen   +6 more
doaj   +1 more source

Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity [PDF]

, 2012
An attenuation of the HIV-1 replication capacity (RC) has been observed for immune-mediated escape mutations in Gag restricted by protective HLA alleles.
Olvera, A., Markle, T.J., Cheung, P.K., John, M., Brumme, Z.L., Brumme, C.J., Carlson, J.M., Kelleher, A.D., Markowitz, M., Frahm, N., McGovern, R., Harrigan, P.R., Brander, C., Heckerman, D., Sanchez, J., Walker, B.D., Chopera, D.R., Sela, J., Le, A.Q., Jessen, H., Martin, E., Rosenberg, E., Brockman, M.A., Mallal, S.   +23 more
core  

The role of dolutegravir in the management of HIV infections

Infection and Drug Resistance, 2015
Misty M Miller,1 Michelle D Liedtke,1 Staci M Lockhart,2 R Chris Rathbun1 1Department of Pharmacy: Clinical and Administrative Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA; 2AbbVie Inc., Oklahoma City, OK, USA Abstract ...
Miller MM, Liedtke MD, Lockhart SM, Rathbun RC   +3 more
doaj  

HIV-1 integrase strand transfer inhibitors with reduced susceptibility to drug resistant mutant integrases

, 2020
HIV integrase (IN) strand transfer inhibitors (INSTIs) are among the newest anti-AIDS drugs; however, mutant forms of IN can confer resistance. We developed noncytotoxic naphthyridine-containing INSTIs that retain low nanomolar IC50 values against HIV-1 ...
Valerie E Pye (8128395), Christophe Marchand (43010), Terrence R Burke (9449126), Mathieu Metifiot (1397662), Peter Cherepanov (369), Katherine Fesen (1397647), Daniel P Maskell (8307387), Xue Zhi Zhao (1397659), Yves Pommier (11158), Stephen H Hughes (9449123), Steven J Smith (9449120)   +10 more
core  

Role of low-frequency integrase strand transfer inhibitor resistance mutations on virological outcomes in antiretroviral therapy-naïve individuals initiating second-generation integrase inhibitors

Journal of Global Antimicrobial Resistance
Objectives: This study investigated the role of low-frequency integrase strand transfer inhibitor (INSTI) resistance mutations, detectable by next-generation sequencing (NGS), at predicting virological rebound (VR) among people with HIV (PWH) starting ...
Daniele Armenia, Greta Marchegiani, Daniele Spalletta, Luca Carioti, Alessandro Tavelli, Maria Concetta Bellocchi, Vincenzo Spagnuolo, Valentina Mazzotta, Eugenia Quiros-Roldan, Valeria Bono, Stefania Carrara, Sergio Lo Caputo, Antonella D’Arminio Monforte, Francesca Ceccherini-Silberstein, Stefano Rusconi, Maria Mercedes Santoro   +15 more
doaj   +1 more source