Results 51 to 60 of about 2,882,240 (203)

Brief Histories of Retroviral Integration Research and Associated International Conferences

Viruses
The field of retroviral integration research has a long history that started with the provirus hypothesis and subsequent discoveries of the retroviral reverse transcriptase and integrase enzymes.
Duane P. Grandgenett, Alan N. Engelman
doaj   +1 more source

Will Drug Resistance against Dolutegravir in Initial Therapy Ever Occur?

Frontiers in Pharmacology, 2015
Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI) and INSTIs are the latest class of potent anti-HIV drugs. Compared to the first generation INSTIs, raltegravir (RAL) and elvitegravir (EVG), DTG shows a limited cross ...
Mark eWainberg, Yingshan eHan
doaj   +1 more source

Integrase strand transfer inhibitors and neuropsychiatric adverse events in a large prospective cohort

, 2019
International audienceTo analyse the frequency and causes of treatment discontinuation in patients who were treated with an integrase strand transfer inhibitor (INSTI), with a focus on neuropsychiatric adverse events (NPAEs)
Hue, H, Breaud, S, Miailhes, P, Nguyen, D, Montes, B, Meybeck, A, Perré, P, Laurichesse, H.,, Lanternier, F., Najioullah, F, Toméi, C, Miailhes, P., Hall, N, Santos, G Dos, Duvivier, C., May, T., Cua, E, Valette, M., Danion, F, Hustache-Mathieu, L, Berger, J., Robineau, O, Rey, David, Cavellec, M, Rouzaud, C, Chidiac, C., Chansombat, M, Ferré, V, Charlier, C, Mrozek, N, Corbin, V., V., Makinson, A, Fourreau, F, Batard, M, Reliquet, V, Pradier, C, André, M., Roux, S., Ritleng, A, Naqvi, A, Carta-Padovani, M, Naqvi, A., Morgand, M, Schneider, L, Roux, Stéphane, Aumeran, C., Lerolle, N, Valantin, M, Tomei, C., Lanternier, F, Casanova, S., Touam, F, Hentzien, M., Delobel, P., Rouzioux, C, Orticoni, M, Le Moing, V, Jovelin, T., Launay, M., Point, P, Vittecoq, D, Ferrando, S, Bouchez, S, Joly, V, Ravaux, I, Blanc, C, Biron, C, Pradier, M, Dournon, N, Degroodt, S, Biron, F, Debard, A., Hentzien, M, Guimard, T, Dhiver, C, Charpentier, C., Delestan, M, Pallier, C., Peytavin, G, Boutoille, D., Etienne, N, Tubiana, R, HALL, N., Leautez, S, Breaud, S., Bernaud, C, Landman, R, Priester, M, Muret, P., Lamaury, I, Drobacheff-Thiébaut, C, Rio, V, Guery, R, Etienne, C, Chidiac, C, Pierre-François, S, Ravaux, I., Ducassou, M., Cottalorda, J., Durant, J., Goesch, J, Lafon-Desmurs, B, CORBIN, V., Poizot-Martin, I, Lepiller, Q., Chirouze, C., Joulie, A, Ouissa, R, Bollangier, O, Letertre, P, Poizot-Martin, I., Delpierre, C., Bani-Sadr, Firouzé, Cotte, L, Lesens, O, Boucher, A., Alcaraz, I, Muret, P, Hall, N.,, Mondain, V, Risso, K, Rahli, D, Seang, S, Meftah, N, Matheron, S, Cottalorda, J, Avettand Fenoel, V, Lebrun, D., Ducassou, M, Alvarez, M., Meftah, N., Lefebvre, M, Valour, F, Caby, F, Goujard, C, Pallier, C, Babre, O, Barrail-Tran, A, Danion, F., Rosenthal, E., Melliez, H, Césaire, R., Deradji, O, Obry-Roguet, V, Abel, S, Fischer, P, Billaud, E., Charlier, C., Belkhir, A., Lions, C, Cabié, André, Billaud, E, Huleux, T., Montes, B., Jovelin, T, Curlier, E, Césaire, R, Caby, F., Hoen, B, Courjon, J, Laurichesse, H, Partisani, M, Mokhtari, M Saadia, Piffaut, M, Kmiec, I, Rodallec, A, Reynes, Jacques, Meddeb, L, Herrmann-Storck, C, Moing, V Le, Pasquier, J., Meddeb, L., Baud, O., Illiaquer, M, Launay, M, Baud, O, Sécher, S, Morineau, P, Reliquet, V., Oran, N, Flandre, P, Raffi, F., Frésard, A., Aubry, O, Cuzin, Lise, Galinier, A., Descamps, D., Pasquier, J, Godard, C, Julia, Z, Gagneux-Brunon, A, Pilmis, B., Parize, P, Brunet-Cartier, C, May, T, Cheret, A, Lesens, O., Henry, B, Katlama, Christine, Aumeran, C, Pilmis, B, Luquet-Besson, I, Hoen, B., Debard, A, Fuzibet, J, Raffi, F, Pircher, M., Pircher, M, Gervais, A, Belkhir, A, Ménard, A, Lepiller, Q, Casanova, S, Wehrlen-Pugliese, S, Valour, F., Lerolle, N., Valette, M, Schepers, K, Vittecoq, D., Allavena, Clotilde, Soria, A, Dupont, H Tissot, Pasquet, A., Oran, N., Yazdanpanah, Y., Zaegel-Faucher, O., Gilquin, J, Biron, F., Monclar, M, Matheron, S., Flandre, P., Berger, J, Ivanova, A., Monte, a De, Guen, L Le, Ouka, M, Brodard, V, Boyer, L, Bregigeon, Sylvie, Baclet, V, Morrier, M, Delobel, P, Rozé, B, Dellamonica, P., Bouiller, K., Viget, N, Duvivier, C, Ferry, Tristan, LAURICHESSE, H., Lortholary, O, Durant, J, Louni, F, Zouzou, G, Botelho-Nevers, E., Consigny, P, Boucher, A, Cotte, L., Point, P., Lambert, D, Hocqueloux, L, Lariven, S, Boyer, L., Jacomet, C, Makinson, A., Lions, C., Parize, P., Lelièvre, L, Peytavin, G., Boutoille, D, Rioux, C, Cheneau, C, Ceppi, C, Lelievre, L., Pillet, S, Lebrun, D, Martin-Blondel, G, Charpentier, C, Huleux, T, Bertone, H, Soria, A., Metsu, D, Lambert, D., Perpoint, T, Pillet, S., Ader, F., Dhiver, C., André, M, Khatchatourian, L, Biezunski, N, Choisy, P, Bernard-Henry, C, Rouzioux, C., Bouiller, K, Amazzough, K., Soavi, M, Delpierre, C, Hall, N., M.J., Bouillon, M, Botelho-Nevers, E, Lansalot, P, Blanco-Betancourt, C, Rodallec, A., Yazdanpanah, Y, Cessot, G, Martin-Blondel, Guillaume, Galinier, A, Chirouze, C, Porte, L., Benabdelmoumen, G, Gagneux-Brunon, A., Galie, S, Grossi, O, Corbin, V.,, Perpoint, T., Teicher, E., Delobel, Pierre, Laurichesse, H., H., Corbin, V, Louisin, C, Boibieux, A, Prouvost-Keller, B, Rioux, C., Lescure, F., Ressiot, E, Lucht, F., Rosenthal, E, Foltzer, A, Pugliese, Pascal, Cheneau, C., Aubry, O., Sausse, S, Mackoumbou-Nkouka, C, Ivanova, A, Vidal, M, Dellamonica, P, Brochier, C, Zaegel-Faucher, O, Porte, L, Atoui, N, Fagour, L, N’guyen, Y, Bossi, P, Fabre, I, Perbost, I, Ajana, F, Boibieux, A., Quertainmont, Y, Lescure, F, Obry-Roguet, V., Pasquet, A, Ferre, V., Morgand, M., Mondain, V., de Mautort, E, André-Garnier, E, Guery, R., Partisani, M., Alvarez, M, Descamps, D, Frésard, A, Lourenco, Jeremy, Bozon, F, Joulié, A., Najioullah, F., Bonnet, B, Lucht, F, André-Garnier, E., Demonchy, E, Agher, R, Merrien, D, Garraffo, R, Amazzough, K, Montoya Ferrer, A., Lafon-Desmurs, B., Palich, R, Ferrer, a Montoya, de Boever, C Merle, Perré, P., Saune, K, Abel, S., Lortholary, O., Ader, F, Teicher, E   +382 more
core   +1 more source

The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions. [PDF]

PLoS ONE, 2010
Resistance to HIV-1 integrase (IN) inhibitor raltegravir (RAL), is encoded by mutations in the IN region of the pol gene. The emergence of the N155H mutation was replaced by a pattern including the Y143R/C/H mutations in three patients with anti-HIV ...
Sandrine Reigadas, Guerric Anies, Bernard Masquelier, Christina Calmels, Lieven J Stuyver, Vincent Parissi, Herve Fleury, Marie-Line Andreola   +7 more
doaj   +1 more source

Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-brain barrier integrity and function

Frontiers in Pharmacology, 2023
The implementation of combined antiretroviral therapy (cART) significantly reduces the mortality associated with human immunodeficiency virus (HIV) infection.
Chang Huang, Tozammel Hoque, Reina Bendayan   +2 more
doaj   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Transmission of Integrase Strand-Transfer Inhibitor Multidrug-Resistant HIV-1: Case Report and Response to Raltegravir-Containing Antiretroviral Therapy

, 2011
We report the case of an integrase strand-transfer inhibitor (INI)-resistant and four-drug-class-resistant HIV-1 variant infecting an antiretroviral therapy-naive man.
Marty St Clair, Belinda Ha, Benjamin Young, Amy Thomas, Christos J Petropoulos, Sharon Martens, Signe Fransen, Kenneth S Greenberg   +7 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Development of an HIV-1 integrase enzyme strand transfer assay [PDF]

, 2011
The Human Immunodeficiency Virus type 1 (HIV-1) integrase is an essential enzyme required for viral replication. Integrase forms part of an ensemble of proteins known as the preintegration complex and functions by a two-step process.
Qasim, Muhammad
core  

The first total synthesis of lamellarin α 20-sulfate, a selective inhibitor of HIV-1 integrase [PDF]

, 2006
The first total synthesis of lamellarin α 20-sulfate (1), a selective inhibitor of HIV-1 integrase, has been completed. The lamellarin α core in which 13-OH and 20-OH were differentially protected by isopropyl and benzyl groups, respectively, was ...
Iwao, Masatomo, Ishibashi, Fumito, Yamaguchi, Tomohiro, Fukuda, Tsutomu   +3 more
core   +1 more source