Results 81 to 90 of about 2,882,240 (203)

Homogeneous high-throughput screening assays for HIV-1 integrase 3beta-processing and strand transfer activities.

, 2005
HIV-1 integrase (HIV-IN) is a well-validated antiviral drug target catalyzing a multistep reaction to incorporate the HIV-1 provirus into the genome of the host cell.
Wolff, Karen, Brinker, Achim, Gunderson, Drew, Caldwell, Jeremy, Scott Lesley, Drew Gunderson, Karen Wolff, Heath Klock, Kirk Niswonger, Yu Wang, Jeremy Caldwell, Yin, Hong, Wang, Yu, Hong Yin, Klock, Heath, Lesley, Scott, Achim Brinker, Kimberly Bieza, Matzen, Jason, Hale, Joanna, Jason Matzen, Kelli Kuhen, Kuhen, Kelli, Bieza, Kimberly, Joanna Hale, Niswonger, Kirk   +25 more
core   +1 more source

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases [PDF]

, 2016
HIV integrase (IN) strand transfer inhibitors (INSTIs) are among the newest anti-AIDS drugs; however, mutant forms of IN can confer resistance. We developed noncytotoxic naphthyridine-containing INSTIs that retain low nanomolar IC50 values against HIV-1 ...
Christophe Marchand (43010), Burke, TR, Katherine Fesen (1397647), Cherepanov, P, Stephen H. Hughes (1397653), Xue Zhi Zhao (1397659), Yves Pommier (11158), Terrence R. Burke (1397665), Marchand, C, Pye, VE, Smith, SJ, Daniel P. Maskell (1397650), Steven J. Smith (1397668), Mathieu Metifiot (1397662), Peter Cherepanov (369), Hughes, SH, Maskell, DP, Pommier, Y, Zhao, XZ, Fesen, K, Valerie E. Pye (1397656), Metifiot, M   +21 more
core   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Development of an HIV-1 intergrase enzyme strand transfer assay [PDF]

, 2012
M.Sc.(Med.) (Molecular Medicine and Haematology), Faculty of Health Sciences, University of the Witwatersrand, 2011The Human Immunodeficiency Virus type 1 (HIV-1) integrase is an essential enzyme required for viral replication.
Fish, Muhammad Qasim
core  

In Vitro Targeting of Strand Transfer by the Ty3 Retroelement Integrase* [PDF]

, 2012
The Saccharomyces cerevisiae long terminal repeat retrotransposon Ty3 integrates within one or two nucleotides of the transcription initiation sites of genes transcribed by RNA polymerase III.
Sandmeyer, Suzanne, Qi, Xiaojie
core   +1 more source

Transposons as Tools for Future Genome Engineering in Yeasts and Filamentous Fungi

Yeast, EarlyView.
Applications of transposon‐based tools for genome engineering in fungi include transposon‐mediated mutagenesis and targeted genomic integration. ABSTRACT Transposons are fundamental genetic elements that have profoundly shaped the architecture of eukaryotic genomes.
Bingyin Peng, Masahiro Tominaga, Chengqiang Wang, Robert E. Speight, Jun Ishii   +4 more
wiley   +1 more source

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

Dietary counselling and exercise training for lipid management in people living with HIV: A systematic review and meta‐analysis

HIV Medicine, EarlyView.
Abstract Objectives Dyslipidaemia is highly prevalent among people living with human immunodeficiency virus (HIV) and contributes to increased cardiovascular risk. Although lifestyle interventions are recommended, evidence specific to people living with HIV remains limited. Previous reviews have primarily focused on dietary interventions or low‐density
Maki Aomori, Hitomi Maeda
wiley   +1 more source

Stability of the HIV cascade of care throughout the COVID‐19 pandemic in Europe: Results from the multinational EuroSIDA cohort study (2016–2022)

HIV Medicine, EarlyView.
Abstract Background Prior to the COVID‐19 pandemic, antiretroviral therapy (ART) coverage and viral suppression were improving across Europe; however, the impact of the pandemic on HIV care remains uncertain. Methods In‐person visits, ART coverage and viral suppression among those on ART were described in the EuroSIDA cohort for each calendar year from
Olga Fursa, Wendy Bannister, Giovanni Guaraldi, Justyna Kowalska, Jose M. Miro, Robert Zangerle, David Jilich, Jean‐Paul Viard, Katharina Kusejko, Piotr Nowak, Pere Domingo, Claire Mackintosh, Antonella Castagna, Thomas Benfield, Bartosz Szetela, Johannes Bogner, Marta Boffito, Lars Peters, on behalf of the EuroSIDA study group   +18 more
wiley   +1 more source

Non-integrase mechanisms for dolutegravir resistance

Retrovirology
Background Antiretroviral inhibitors that target specific aspects of human immunodeficiency virus 1 (HIV-1) replication have made a huge impact on the management of the global AIDS pandemic and the health and well-being of people that live with HIV ...
Alan N. Engelman
doaj   +1 more source