Results 151 to 160 of about 2,862,567 (165)

Ruthenium arene complexes as HIV-1 integrase strand transfer inhibitors

Journal of Inorganic Biochemistry, 2013
The quinolone HL1 and the hydroxypyrimidine-carboxamide HL2 were designed and synthesized as models of the HIV integrase strand transfer inhibitors Elvitegravir and Raltegravir (brand name Isentress), with the aim to study their complexing behavior and ...
Alessia Bacchi, Mauro Carcelli, Paolo Pelagatti   +2 more
exaly   +2 more sources

New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action

Bioorganic and Medicinal Chemistry, 2010
The life cycle of HIV-1 requires extensive assistance from the integrase (IN) enzyme which therefore constitutes an attractive therapeutic target for the development of anti-AIDS agents. We herein report the synthesis and biological evaluation of new HIV
Frauke Christ, Zeger Debyser, Laura De Luca   +2 more
exaly   +3 more sources

Impact of HIV-1 Integrase L74F and V75I Mutations in a Clinical Isolate on Resistance to Second-Generation Integrase Strand Transfer Inhibitors.

Antimicrobial Agents and Chemotherapy, 2017
A novel HIV-1 integrase mutation pattern, L74F V75I, which conferred resistance to first-generation integrase strand transfer inhibitors (INSTIs), was identified in a clinical case with virological failure under a raltegravir-based regimen.
Yasumasa Iwatani, Stefan G. Sarafianos, Karen A. Kirby   +2 more
exaly   +2 more sources

Antiviral activity of HIV-1 integrase strand-transfer inhibitors against mutants with integrase resistance-associated mutations and their frequency in treatment-naïve individuals

Journal of Medical Virology, 2019
<p>The development of  resistance to human immunodeficiency virus 1 (HIV-1) integrase strand-transfer inhibitors (INSTI) has been documented; however, knowledge of the impact of pre-existing integrase (IN) mutations on INSTI resistance (INSTI-R) is
Nicolas A Margot, Michael E Abram, Kirsten White   +2 more
exaly   +2 more sources

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Advances in the development of HIV integrase strand transfer inhibitors

European Journal of Medicinal Chemistry, 2021
Renhua Fan, Shuang-Xi Gu, Qiuqin He
exaly  

Do All Integrase Strand Transfer Inhibitors Have the Same Lipid Profile? Review of Randomised Controlled Trials in Naïve and Switch Scenarios in HIV-Infected Patients

Journal of Clinical Medicine, 2021
Daniel Podzamczer, Maria Saumoy, Jose Luis Sanchez-Quesada   +2 more
exaly  

Drug Resistance to Integrase Strand-Transfer Inhibitors among HIV-1-Infected Adults in Guangdong, China

Pathogens, 2022
Linghua Li, Weiping Cai, Fengyu Hu
exaly  

Synthetic Approaches to a Key Pyridone-carboxylic Acid Precursor Common to the HIV-1 Integrase Strand Transfer Inhibitors Dolutegravir, Bictegravir, and Cabotegravir

Organic Process Research and Development, 2023
Terrence R Burke
exaly  

Preliminary report of transmitted drug resistance to integrase strand chain transfer inhibitors in treatment-naïve HIV infected patients

Diagnostic Microbiology and Infectious Disease, 2023
Pablo Ferrer
exaly  

Integrase strand transfer inhibitors in the management of HIV-positive individuals

Annals of Medicine, 2014
Veronica Zanichelli, Thibault Mesplède, Peter K Quashie   +2 more
exaly