Results 151 to 160 of about 2,770,732 (298)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

WHF Roadmap for Integrated Care in People Living with - or at Risk of - Cardiovascular Disease and Multiple Long-Term Conditions. [PDF]

Glob Heart
Sperling L, Irazola V, Partarrieu J, Raspail L, Banach M, Banerjee A, Bukhman G, George M, Toda Kato E, Lopez-Jimenez F, Macari S, Miranda J, Mocumbi A, Perel P, Prabhakaran D, Puente Barragan A, Sherifali D, Santos R.   +17 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Toward Integrated Care for Neurogastroenterology and Motility Disorders: A Model for Clinical Practice. [PDF]

Clin Exp Gastroenterol
Veldman FHC, Sweerts KWE, Leue C, Brouns J, Mulkens S, Brans Brabant B, Beckers RCJ, Conchillo JM, Keszthelyi D.   +8 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The integration of communicable and non-communicable disease (CD-NCD) health services in Africa: A scoping review. [PDF]

PLOS Glob Public Health
Hlatshwako TG, Ale O, Chapola J, Jiao L, Song S, Yao A, Frerichs L, Templin T.   +7 more
europepmc   +1 more source

Federal Court Cases: Integrated Data Base Bankruptcy Petitions, 1994

, 1994
Federal Judicial Center
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Unnatural Cytosine Analogs Potentiate a Customizable, Enzymatic Method for Integrated Epigenetic and Four-Base Genetic Sequencing. [PDF]

J Am Chem Soc
Loo CE, Parker JB, Barka A, Zhu R, Schnell MR, Cuomo RG, Zhu H, Liu L, Chen A, Gill J, Zhou W, Kohli RM.   +11 more
europepmc   +1 more source

Flood Hazard Assessment of the Bangshi River Floodplain using an Integrated 1D/2D Coupled Hydraulic Model

, 2022
Md. Jakir Hossain, ASM Maksud Kamal, Md. Shakhawat Hossain, Md. Mostafizur Rahman, Md. Zillur Rahman   +4 more
openalex   +2 more sources