Results 101 to 110 of about 7,533,094 (293)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Singapore Programme for Integrated Care for the Elderly (SPICE)—an integrated model of care to enable frail elderly to be cared for in the community

International Journal of Integrated Care, 2012
Chun Keong, Loong Mun, Leo Feng, Josephine Huang, Jason Cheah   +4 more
doaj   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Integrated and interprofessional care

International Journal of Integrated Care, 2012
No wonder two movements described in such similar terms are so often confused. One strives to knit services together, the other to cultivate collaborative practice amongst their workers. Dedicated though both of them are to the improvement of health and social care, integrated care falters without engaging the workforce actively as partners in change ...
openaire   +6 more sources

Enabling Integrated Health and Care

, 2016
https://integratedcarefoundation.org/events/icic16-16th-international-conference-integrated-care-barcelonaVoR - Version of ...
Claire Naumann, Hou, TH, Nicolette Sheridan, Timothy W Kenealy, Rolland, T-M, Timothy Hou Hou, Ta-Mera Rolland, Harry H Rea, Naumann, C, Kenealy, T, Sheridan, N, Rea, H   +11 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Evaluation of complex integrated care programmes: the approach in North West London [PDF]

, 2013
Background: Several local attempts to introduce integrated care in the English National Health Service have been tried, with limited success. The Northwest London Integrated Care Pilot attempts to improve the quality of care of the elderly and people ...
Car, J, Holder, H, Soljak, M, Gunn, L, Harris, M, Pappas, Y, Bardsley, M, Curry, N, Blunt, I, Majeed, A, Greaves, F   +10 more
core   +1 more source

The Singapore experience: understanding the older persons who utilize community rehabilitation services

International Journal of Integrated Care, 2013
J. Ong, M. Lim, L. Seong
doaj   +3 more sources

Healthcare social network research and the ECHO model™: Exploring a community of practice to support cultural brokers and transfer cultural knowledge

BMC Health Services Research
Background Project ECHO® networks at Children’s Health Queensland Hospital and Health Service (CHQHHS) are communities of practice designed to mitigate services and systems fragmentation by building collaborative partnerships addressing priority child ...
Phil Nixon, Chiara Broccatelli, Perrin Moss, Sarah Baggio, Angela Young, Dana Newcomb   +5 more
doaj   +1 more source

Evaluating the role of the Diabetes Prevention Programme in the Tallaght Community Integrated Care Hub.

The Tallaght Community Integrated Care Hub is one of 30 Hubs in the Republic of Ireland established as part of the Enhanced Community Care (ECC) programme.
O'Loughlin, Gillian, O'Shea, Fiona, Curley, Peter, Ring, Lisa, Parke, Lynda, Sheane, Rachel, Ramsay, Claire, Power, Nicole   +7 more
core