Results 121 to 130 of about 7,533,094 (293)
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Integrated care requires integrated supervision
International Journal of Integrated Care, 2011 Given recent developments in integrated care, it is becoming increasingly important for the Dutch Health Care Inspectorate to direct its supervision in a way that may help speed up the implementation of integrated care.Since the implementation of integrated care for chronic patients is facing obstacles, alternative methods are required to ensure that ...
openaire +6 more sources
The Irish health service model of integrated care for people living with type 2 diabetes (2018, 2024) and the ICPCD recommends self-management education and support (SMES) as essential to quality care.
McGowan, Ciara +3 more
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Transitional Care Programme Evaluation – The Singapore Experience
International Journal of Integrated Care, 2013 Patsy Chow, Loong Mun Wong, Jason Cheah
doaj +3 more sources
Severe disseminated tuberculosis complicated by polyneuropathy: a case report and literature review
BMC Infectious DiseasesBackground Tuberculosis is a great public health concern. Disseminated tuberculosis carries a high mortality. Polyneuropathy is a rare but serious complication in patients with tuberculosis.
Xiaoqing Huang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Theory-driven evaluation of Integrated Health and Social Care Programs in the Apulia Region [PDF]
, 2016 Service delivery has traditionally developed in ways that have tended to fragment care. In the last decades, however, the growing numbers of people with complex needs (i.e.
Lucia, Ferrara, Giuseppe, Moro
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source