Results 121 to 130 of about 8,967,918 (378)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Pectoralis major muscle sarcoma masquerading breast lesion: A rare case report with review of literature

Radiology Case Reports, 2023
Pectoralis major muscle sarcomas are extremely rare and can mimic breast lesion clinically. We report a case of poorly differentiated sarcoma of the pectoralis major muscle in a 63-year-old woman of south east Asian ethnicity presenting with a ...
Anamika Kumar, MD, DNB, Pranjali Joshi, MD, Satish Chaitanya K, MS, Bhagyashree Singh, MD, Ananya Deori, MS, Prateek Sharda, MS, Bina Ravi, MS, FRCS, Anjum Syed, MD, FRCR   +7 more
doaj  

Shaping the future for primary care education and training project. Education and training provision to deliver integrated health & social care: course finder [PDF]

, 2006
Within the Shaping the Future for Primary Care Education and Training Project, the literature review concerning integrated health and social care identified a number of implications or recommendations for service and education.
Hardiker, NR
core  

Introducing Care 4.0: An Integrated Care Paradigm Built on Industry 4.0 Capabilities

International Journal of Environmental Research and Public Health, 2019
Western developed health and care policy is shifting from a patriarchal medical model to a co-managed and integrated approach. Meanwhile, the fourth industrial revolution (Industry 4.0) is transforming manufacturing in line with the digital consumer ...
C. Chute, T. French
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Collaborative modeling of an implementation strategy: a case study to integrate health promotion in primary and community care

BMC Research Notes, 2017
Background Evidence-based interventions are more likely to be adopted if practitioners collaborate with researchers to develop an implementation strategy.
Gonzalo Grandes, Alvaro Sanchez, Josep M. Cortada, Haizea Pombo, Catalina Martinez, Laura Balagué, Mary Helen Corrales, Enrique de la Peña, Justo Mugica, Esther Gorostiza, on behalf of the PVS group   +10 more
doaj   +1 more source

Similar mortality and reduced loss to follow-up in integrated compared with vertical programs providing antiretroviral treatment in sub-saharan Africa. [PDF]

, 2012
Vertical HIV programs have achieved good results but may not be feasible or appropriate in many resource-limited settings. Médecins sans Frontières has treated HIV in vertical programs since 2000 and over time integrated HIV treatment into general health
Bellera, Boulle, Brinkhof, Coviello, Denny, Janssens, OBrien, OBrien   +7 more
core   +2 more sources

The (cost‐)effectiveness of preventive, integrated care for community‐dwelling frail older people: A systematic review

Health and Social Care in the community, 2018
Integrated care is increasingly promoted as an effective and cost‐effective way to organise care for community‐dwelling frail older people with complex problems but the question remains whether high expectations are justified.
W. Looman, R. Huijsman, I. Fabbricotti
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Emerging needs in behavioral health and the integrated care model [PDF]

, 2016
Medically vulnerable populations are constantly at risk of having poor health related outcomes, low satisfaction in the healthcare system and increased mortality.
Read, Taylor Lynn
core   +1 more source