Results 91 to 100 of about 554,536 (332)

Emerging needs in behavioral health and the integrated care model [PDF]

, 2016
Medically vulnerable populations are constantly at risk of having poor health related outcomes, low satisfaction in the healthcare system and increased mortality.
Read, Taylor Lynn
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Epilepsy care pathway: The Finnish model

Epilepsia Open
Objective Integrated care pathways are essential for consistent, effective epilepsy care, offering equal access and quality regardless of socioeconomic status.
Reetta Kälviäinen, Zakarya Hadj‐Allal, Jarkko Kirjavainen, Reina Roivainen, Tarja Linnankivi, Jukka Peltola, Kai Eriksson, Salla Lamusuo, Tuire Lähdesmäki, Johanna Annunen, Päivi Vieira, Virpi Tarkiainen, Leena Jutila, Anni Saarela, Leena Kämppi, Liisa Metsähonkala, Eija Gaily, Niina Lähde, Jaana Antinmaa, Sini Erme, Anna‐Leena Pirttisalo, Jari Virolainen, Milla Ylijoki, Laura Kela, Jonna Komulainen‐Ebrahim, Paula Sorjonen, Finnish Severe Epilepsy Coordination Group   +26 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Planning, implementation and operation of a personalized patient management system for subjects with first suspect of cancer (OnkoNetwork): system description based on a qualitative study

BMC Health Services Research, 2019
Background OnkoNetwork is a recently established integrated care model with a personalized pathway system to manage patients with first suspect of a solid tumour in secondary care, that evolved as a regional initiative in Hungary.
János G. Pitter, Marcell Csanádi, Annamária Szigeti, Gábor Lukács, Árpád Kovács, Mariann Moizs, Imre Repa, Antal Zemplényi, Thomas Czypionka, Markus Kraus, Maureen P. M. H. Rutten-van Mölken, Zoltán Kaló   +11 more
doaj   +1 more source

Effective Approaches With Young Adults: A Guide for Probation Services [PDF]

, 2015
The aim of this guide is to give probation practitioners, whether in the National Probation Service or Community Rehabilitation Companies, the tools to deliver a more effective approach to young adults.
Isabel Livingstone, Louise Clark, Suleman Amad   +2 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Intersectoral pathways of vulnerable patient groups in Southern Denmark

International Journal of Integrated Care, 2014
Stine Lundstroem Kamionka, Niels Buus, Morten Sodemann, Peer Noehr-Jensen, Kim Juul Larsen   +4 more
doaj   +3 more sources

Regional Integrated Cardiovascular Risk Management Care Pathway in the Netherlands: Benefits and Working Mechanisms

International Journal of Integrated Care
Background: Integrated cardiovascular risk management care pathways are initiated nationwide to decrease the morbidity, mortality, and costs of cardiovascular diseases.
Relinde J. de Koeijer, Marcella E. de Geest, Gideon R. Hajer, Fabrice M. A. C. Martens   +3 more
doaj   +1 more source

A Multiple Method Evaluation of the Mid Essex Memory Assessment and Support Service [PDF]

, 2010
On 3rd February 2009, the Department of Health published “Living well with dementia: A National Dementia Strategy”. This proposed a series of changes to the way services for people with dementia are organised and delivered, from raising awareness and ...
Hean, Sarah, Warr, Jerry
core