Results 91 to 100 of about 234,975 (247)

Living beyond placenta accreta spectrum: parent's experience of the postnatal journey and recommendations for an integrated care pathway. [PDF]

BMC Pregnancy Childbirth, 2022
Bartels HC, Horsch A, Cooney N, Brennan DJ, Lalor JG.   +4 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A cost-effectiveness study of cost of care and health consequences for two modes of treatment for patients with hip fractures

International Journal of Integrated Care, 2008
Lars-Eric Olsson, Elisabeth Hansson, Inger Ekman, Jón Karlsson   +3 more
doaj   +3 more sources

Evaluation of an integrated care pathway for out-of-hospital treatment of older adults with an acute moderate-to-severe lower respiratory tract infection or pneumonia: protocol of a mixed methods study. [PDF]

BMJ Open, 2023
Roos R, Pepping RMC, van Aken MO, Labots G, Lahdidioui A, van den Berg JMW, Kolfschoten NE, Pasha SM, Ten Holder JT, Mollink SM, van den Bos F, Kant J, Kroon I, Vos RC, Numans ME, van Nieuwkoop C.   +15 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The Geriatric Hearcare Services as an example of integrated ‘pathway’ in case- and care management

International Journal of Integrated Care, 2009
Michael Lerch, Mechthild Decker-Maruska
doaj   +3 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

10 Years experience of developing an Integrated Care Model for people with dementia in Catalonia

International Journal of Integrated Care, 2015
Isabel Fort Almiñana, Begoña Bodegas Valpuesta, Anna Ferré Jodra, Sebastià J. Santaeugènia Gonzàlez, Miquel Àngel Mas Bergas, Anna Mas Vidal, Lourdes Ispierto, Milagrosa Blanca Tamayo, Dunia Perdrix Solàs, Maria José Ciudad Mas, Miriam Rovira Fargas, Javi Afonso Argiles   +11 more
doaj   +3 more sources

Evaluation of the impact of an integrated care pathway for pulmonary embolism: a quasi-experimental pre-post study. [PDF]

J Thorac Dis, 2021
Rodríguez-Núñez N, Ruano-Raviña A, Lama A, Ferreiro L, Ricoy J, Álvarez-Dobaño JM, Suárez-Antelo J, Toubes ME, Rábade C, Golpe A, Riveiro V, Casal A, Abelleira R, González-Barcala FJ, González-Juanatey JR, Valdés L.   +15 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source