Results 131 to 140 of about 214,412 (248)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Implementation of an integrated care pathway for severe aortic stenosis: a prospective cohort study of clinical profiles, safety, and outcomes. [PDF]

Front Cardiovasc Med
González-Salvado V, Sestayo Fernández M, Alonso-Vázquez M, de la Fuente-López P, Laranjeira Correia JM, Lens-Bravo U, Ruzo-Cedillo Á, Villamayor-Blanco B, González-Juanatey JR, Peña-Gil C.   +9 more
europepmc   +1 more source

The Exponential Phase of the Covid-19 Pandemic in Central Italy: An Integrated Care Pathway. [PDF]

Int J Environ Res Public Health, 2020
Capalbo C, Aceti A, Simmaco M, Bonfini R, Rocco M, Ricci A, Napoli C, Rocco M, Alfonsi V, Teggi A, Orsi GB, Borro M, Santino I, Preissner R, Marchetti P, Marcolongo A, Anibaldi P.   +16 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Improving the management of acute asthma in children through an integrated care pathway: an implementation study protocol. [PDF]

Front Pediatr
Montejo M, Paniagua N, Sanchez A, Rueda-Etxebarria M, Pijoan JI, Saiz Hernando C, Martin V, Vázquez Ronco MA, Santiago Burruchaga M, García Urabayen D, Pérez Llarena G, Castelo S, Benito J.   +12 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Youth partner engagement in the development of an integrated care pathway for the treatment of adolescents with depression. [PDF]

J Can Acad Child Adolesc Psychiatry
Prebeg M, Relihan J, Darnay K, Liddell G, McCann E, Szatmari P, Henderson JL, Courtney DB.   +7 more
europepmc   +1 more source

A protocol study of participatory action research: integrated care pathway for pregnant women with heart disease in Indonesia. [PDF]

BMC Health Serv Res, 2020
Yuliyanti S, Utarini A, Trisnantoro L.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source