Results 31 to 40 of about 99,331 (266)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Energy‐Efficient Online Training with In Situ Parallel Computing on Electrochemical Memory Arrays

Advanced Intelligent Systems
The rapid development of deep learning enables significant breakthroughs for intelligent edge‐terminal devices. However, neural network training for edge computing is currently overly dependent on cloud service platforms, resulting in low adaptivity for ...
Yingming Lu, Zhen Yang, Yaoyu Tao, Lei Cai, Teng Zhang, Longhao Yan, Ru Huang, Yuchao Yang   +7 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Piezoelectric MEMS microphones based on rib structures and single crystal PZT thin film

Microsystems & Nanoengineering
In this study, a controllable mass‒frequency tuning method is presented using the etching of rib structures on a single-crystal PZT membrane. The rib structures were optimized to reduce the membrane mass while maintaining the stiffness; therefore, the ...
Zhiwei You, Jinghan Gan, Chong Yang, Renati Tuerhong, Lei Zhao, Yipeng Lu   +5 more
doaj   +1 more source

Development and implementation of algorithms for automatic and robust measurement of the 2D:4D digit ratio using image data

Current Directions in Biomedical Engineering, 2015
Early in the 20th century it could be observed that the finger lengths of second (2D) and fourth digit (4D) represents a sexually dimorphic feature, whereby in general the second digit is longer than the fourth digit for men and vice versa for women.
Koch Robert, Haßlmeyer Erik, Tantinger Daniel, Rulsch Martin, Weigand Christian, Struck Matthias   +5 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Electrothermal co-optimization of 2.5D power distribution network with TTSV cooling

Scientific Reports
Thermal and power integrity management remains a fundamental challenge in 2.5-dimensional (2.5D) integrated microsystem design. This paper proposes an electrothermal co-optimization design methodology for a 2.5D power distribution network with thermal ...
Yang Wang, Changle Zhi, Gang Dong, Daihang Liu, Deguang Yang, Zhangming Zhu   +5 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

A self-powered microsystem with efficient power management for continuous wireless sensing

Microsystems & Nanoengineering
The rapid expansion of the Internet of Things (IoT) has increased the demand for self-powered wireless microsystems, with energy harvesters emerging as a key approach for powering distributed IoT nodes.
Xiangyu Zhao, Zerui Xu, Ziyang Ou, Qingfeng Wu, Yifeng Liu, Yuqi Kang, Philippe Basset, Xiaohong Wang   +7 more
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source