Results 31 to 40 of about 106,874 (266)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Energy‐Efficient Online Training with In Situ Parallel Computing on Electrochemical Memory Arrays

Advanced Intelligent Systems
The rapid development of deep learning enables significant breakthroughs for intelligent edge‐terminal devices. However, neural network training for edge computing is currently overly dependent on cloud service platforms, resulting in low adaptivity for ...
Yingming Lu, Zhen Yang, Yaoyu Tao, Lei Cai, Teng Zhang, Longhao Yan, Ru Huang, Yuchao Yang   +7 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Piezoelectric MEMS microphones based on rib structures and single crystal PZT thin film

Microsystems & Nanoengineering
In this study, a controllable mass‒frequency tuning method is presented using the etching of rib structures on a single-crystal PZT membrane. The rib structures were optimized to reduce the membrane mass while maintaining the stiffness; therefore, the ...
Zhiwei You, Jinghan Gan, Chong Yang, Renati Tuerhong, Lei Zhao, Yipeng Lu   +5 more
doaj   +1 more source

Development and implementation of algorithms for automatic and robust measurement of the 2D:4D digit ratio using image data

Current Directions in Biomedical Engineering, 2015
Early in the 20th century it could be observed that the finger lengths of second (2D) and fourth digit (4D) represents a sexually dimorphic feature, whereby in general the second digit is longer than the fourth digit for men and vice versa for women.
Koch Robert, Haßlmeyer Erik, Tantinger Daniel, Rulsch Martin, Weigand Christian, Struck Matthias   +5 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Electrothermal co-optimization of 2.5D power distribution network with TTSV cooling

Scientific Reports
Thermal and power integrity management remains a fundamental challenge in 2.5-dimensional (2.5D) integrated microsystem design. This paper proposes an electrothermal co-optimization design methodology for a 2.5D power distribution network with thermal ...
Yang Wang, Changle Zhi, Gang Dong, Daihang Liu, Deguang Yang, Zhangming Zhu   +5 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

A self-powered microsystem with efficient power management for continuous wireless sensing

Microsystems & Nanoengineering
The rapid expansion of the Internet of Things (IoT) has increased the demand for self-powered wireless microsystems, with energy harvesters emerging as a key approach for powering distributed IoT nodes.
Xiangyu Zhao, Zerui Xu, Ziyang Ou, Qingfeng Wu, Yifeng Liu, Yuqi Kang, Philippe Basset, Xiaohong Wang   +7 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source