Results 161 to 170 of about 4,706,350 (310)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Decomposed versus integrated control of a one-stage production system [PDF]

open access: yes
This paper considers the case of a one-stage production system with several products and operating under tight production capacity constraints. The production schedule is cyclical, and there are long and sequence dependent setup times.
Broersma, A.L.A.   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Transparency and control in engineering integrated assessment models. [PDF]

open access: yes
Better software engineering such as archiving releases with version control, writing portable code, publishing documentation and results closely tied to the code improves integrated assessment models' transparency and control.
Minh Ha-Duong
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Control and mitigation of dengue and Zika virus transmission in a hospital in Recife, Brazil: a successful experience with an integrated control program against Aedes aegypti. [PDF]

open access: yesParasit Vectors
Candida-Silva HE   +11 more
europepmc   +1 more source

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