Results 61 to 70 of about 2,136,024 (233)

Integrated building performance simulation [PDF]

, 2001
This paper justifies the need for an integrated approach to building performance assessment and provides examples of the technical appraisals that may then be enabled.
Clarke, J.A.
core  

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Nanophotonic soliton-based microwave synthesizers

, 2019
Microwave photonic technologies, which upshift the carrier into the optical domain to facilitate the generation and processing of ultrawide-band electronic signals at vastly reduced fractional bandwidths, have the potential to achieve superior ...
Bouchand, Romain, Guo, Hairun, He, Jijun, Karpov, Maxim, Kippenberg, Tobias J., Liu, Junqiu, Lucas, Erwan, Raja, Arslan S., Riemensberger, Johann, Wang, Rui Ning   +9 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

AIDDL: The AI Domain Definition Language for integrated AI systems

SoftwareX
Practical applications of artificial intelligence frequently benefit from the strengths of multiple individual AI approaches. However, these approaches use different representations for data and models and thus are often difficult to combine.
Uwe Köckemann
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Experiences in Integrated Multi-Domain Service Management

, 1997
Increased competition, complex service provision chains and integrated service offerings require effective techniques for the rapid integration of telecommunications services and management systems over multiple organisational domains.
Bracht, Ralf, Lewis, David, McEwan, Alistair, Redmond, Cliff, Tiropanis, Thanassis, Wade, Vincent P.   +5 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Multiscale dynamic time‐domain simulation of regional integrated energy considering seasonal load difference

Energy Science & Engineering
To improve the multiscale dynamic dispatching and distribution capacity of regional integrated energy, a multiscale dynamic time‐domain dispatching model of regional integrated energy with seasonal load difference is proposed.
Yafei Li, Kejun Qian, Yi Liu, Ying Xie
doaj   +1 more source