Results 71 to 80 of about 2,136,024 (233)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Adaptive integrated weight unsupervised multi-source domain adaptation without source data
Complex & Intelligent SystemsUnsupervised multi-source domain adaptation methods transfer knowledge learned from multiple labeled source domains to an unlabeled target domain. Existing methods assume that all source domain data can be accessed directly.
Zhirui Wang, Liu Yang, Yahong Han
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Method of Ontology Integration for Designing Intelligent Problem Solvers
Applied Sciences, 2019 Nowadays, designing knowledge-based systems which involve knowledge from different domains requires deep research of methods and techniques for knowledge integration, and ontology integration has become the foundation for many recent knowledge ...
Nhon V. Do +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Representation and matching of knowledge to design digital systems [PDF]
, 1988 A knowledge-based expert system is described that provides an approach to solve a problem requiring an expert with considerable domain expertise and facts about available digital hardware building blocks.
Jones, J. U., Shiva, S. G.
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Combining Evidence Sources in Time Domain With Decision Maker’s Preference on Time Sequence
IEEE Access, 2019 Given the fusion problem of uncertain information on the time domain, this paper proposes a time-domain evidence fusion method involving the time sequence of the decision-maker based on evidence theory to give full expression to the influence of dynamic ...
Bo Zhang +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Effector target-guided engineering of an integrated domain expands the disease resistance profile of a rice NLR immune receptor. [PDF]
Elife, 2023 Maidment JHR +11 more
europepmc +1 more source