Results 111 to 120 of about 2,465,688 (305)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Integrated approach to energy harvester mixed technology modelling and performance optimisation

, 2008
An energy harvester is a system consisting of several components from different physical domains including mechanical, magnetic and electrical as well as the external circuits which regulate and store the generated energy.
Al-Hashimi, Bashir, Beeby, Steve, Kazmierski, Tom, Torah, Russel, Wang, Leran   +4 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Energy efficient engine fan component detailed design report [PDF]

The fan component which was designed for the energy efficient engine is an advanced high performance, single stage system and is based on technology advancements in aerodynamics and structure mechanics.
Halle, J. E., Michael, C. J.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The influence and mechanism analysis of aluminum sulfate as an environmentally friendly early strength agent on the properties of cement-based materials

Case Studies in Construction Materials
Environmentally friendly chemical admixtures are becoming important in the cement industry. The research objective of this paper is to use aluminum sulfate as an early-strengthening agent to achieve the goals of a large increase in early strength and a ...
Li-Yi Meng, Yi-Sheng Wang, Runsheng Lin, Xiao-Yong Wang   +3 more
doaj   +1 more source

ECIS: Energy‐Computing Integrated System

Energy Internet
ABSTRACT With the growing demand for deep integration between computing power networks (CPNs) and energy systems (ESs), effective collaboration between these systems has become increasingly crucial. To facilitate such integration, this paper proposes an energy‐computing integrated system (ECIS), which consists of a four‐layer ...
Haoming Zhang, Bonan Huang, Min Zhang, Yushuai Li, Tianyi Li, Yan Zhang   +5 more
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A spectral selective lamellae concentrator system as BI-CPV/T System [PDF]

In warm periods the excess of incoming solar energy into a greenhouse is more than required for the growth of the crop. In particular the near infrared radiation (NIR) part of the incoming radiation is not necessarily.
Janssen, H.J.J., Sonneveld, P.J., Swinkels, G.L.A.M., Tuijl, B.A.J., van   +3 more
core   +2 more sources