Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Integrated care: What strategies and other arrangements support and influence integration at the meso/organisational level? [PDF]
, 2013 Historically, general practice has been the principal access point for health care delivery in the Australian community. Alongside the growing trend in specialised care, there has been increased fragmentation of health care services, particularly for ...
Brown, Lynsey +2 more
core
Developing Patient-Centered Communication Ecosystems in Integrated Health Care Delivery Organizations. [PDF]
Perm J, 2023 Duckro AN +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Basic newborn care and neonatal resuscitation: a multi-country analysis of health system bottlenecks and potential solutions. [PDF]
, 2015 BACKGROUND: An estimated two-thirds of the world's 2.7 million newborn deaths could be prevented with quality care at birth and during the postnatal period.
Bégin, France +10 more
core +2 more sources
Household Transmission of Viral Acute Gastroenteritis Among Participants Within an Integrated Health Care Delivery System, 2014-2016. [PDF]
Open Forum Infect Dis, 2023 Balachandran N +6 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Towards locally based resource allocation in the NHS [PDF]
In a health care system where resources are scarce and the principle of equity is of central concern, mechanisms for the appropriate allocation of resources based on the notion of relating resource use to some concept of need are essential.
Nigel Rice, Peter Smith, Roy Carr-Hill
core
Models of competent care for people with intellectual/developmental disabilities [PDF]
, 2015 This literature review aims to review research studies that have investigated strategies for care coordination through various healthcare delivery models for intellectually/developmentally disabled population (I/DD). This brief offers a set of principles
Singh, Jogeshwar
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source