Results 61 to 70 of about 766,146 (274)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Presupposition, perceptional relativity and translation theory [PDF]

, 2001
The intertwining of assertions and presuppositions in utterances affects the way a text is perceived in the source language (SL) and the target language (TL).
El-Gamal, Ayman
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Development of a Self‐Management Theory‐Guided Discharge Intervention for Parents of Hospitalized Children [PDF]

, 2017
Background Parents of hospitalized children, especially parents of children with complex and chronic health conditions, report not being adequately prepared for self‐management of their child\u27s care at home after discharge.
Gralton, Karen, Johnson, Norah L., Kaul, Molly, Klingbeil, Carol, Lerret, Stacee M., Malin, Shelly, Sawin, Kathleen, Schiffman, Rachel, Thompson, Jamie J., Weiss, Marianne, Zimmanck, Kim   +10 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Mobilizing Minds: Integrated knowledge translation and youth engagement in the development of mental health information resources [PDF]

, 2016
High rates of highly persistent mental health problems can have significantly damaging effects on young adults’ lives, and young adults are less likely to seek treatment for such problems.
Firsten-Kaufman, Emma, Fogarty, Pauline C, Garinger, Christine A, Leonhart, Mark W, Raimundo, Alicia S, Research Group, Mobilizing Minds, Reynolds, Kristin A, Walker, John R   +7 more
core   +3 more sources

Innovation and Integrity in Intervention Research: Conceptual Issues, Methodology, and Knowledge Translation [PDF]

Prevention Science, 2018
In this article, we introduce the special issue entitled Innovation and Integrity in Intervention Science. Its focus is on essential problems and prospects for intervention research examining two related topics, i.e., methodological issues and research integrity, and challenges in the transfer of research knowledge into practice and policy.
Tina, Malti, Andreas, Beelmann, Gil G, Noam, Simon, Sommer   +3 more
openaire   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The Top 100 Highly Cited Original Articles on Immunotherapy for Childhood Leukemia

Frontiers in Pharmacology, 2019
Background: Childhood leukemia is one of the most common cancers in children. As a potential treatment for leukemia, immunotherapy has become a new research hotspot.
Qing Zhong, Bing-Hui Li, Bing-Hui Li, Qi-Qi Zhu, Zhi-Min Zhang, Zhi-Hao Zou, Ying-Hui Jin, Ying-Hui Jin   +7 more
doaj   +1 more source