Results 71 to 80 of about 153,139 (270)

Knowledge acquisition in supply chain partnerships: the role of power [PDF]

, 2012
Knowledge is recognised as an important source of competitive advantage and hence there has been increasing academic and practitioner interest in understanding and isolating the factors that contribute to effective knowledge transfer between supply chain
Ghobadian, A, Ghobadian, A., He, Q, Gallear, D, Gallear, David, He, Qile, He, Q., Ghobadian, Abby, Gallear, D.   +8 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence

Health Promotion and Chronic Disease Prevention in Canada
IntroductionWe investigated the prevalence of new or persistent manifestations experienced by COVID-19 survivors at 3 or more months after their initial infection, collectively known as post-COVID-19 condition (PCC ...
Mohamed Kadry Taher, Talia Salzman, Allyson Banal, Kate Morissette, Francesca R. Domingo, Angela M. Cheung, Curtis L. Cooper, Laura Boland, Alexandra M. Zuckermann, Muhammad A. Mullah, Claudie Laprise, Roberto Colonna, Ayan Hashi, Prinon Rahman, Erin Collins, Tricia Corrin, Lisa A. Waddell, Jason E. Pagaduan, Rukshanda Ahmad, Alejandra P. Jaramillo Garcia   +19 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Integrated knowledge translation guidelines for trainees in health research: an environmental scan

Health Research Policy and Systems, 2023
Abstract Background Collaborative health research, such as integrated knowledge translation (IKT), requires researchers to have specific knowledge and skills in working in partnership with knowledge users. Graduate students are often not provided with the opportunity to learn skills in how to establish collaborative ...
Sarah Madeline Gallant, Christine Cassidy, Joyce Al-Rassi, Elaine Moody, Hwayeon Danielle Shin, Shauna Best, Audrey Steenbeek   +6 more
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Research Coproduction: An Underused Pathway to Impact [PDF]

International Journal of Health Policy and Management
Knowledge translation and implementation science have made many advances in the last two decades. However, research is still not making expedient differences to practice, policy, and service delivery.
Jo Rycroft-Malone, Ian D. Graham, Anita Kothari, Chris McCutcheon   +3 more
doaj   +1 more source

Evaluating research co-production: protocol for the Research Quality Plus for Co-Production (RQ+ 4 Co-Pro) framework

Implementation Science Communications, 2022
Background Research co-production is an umbrella term used to describe research users and researchers working together to generate knowledge. Research co-production is used to create knowledge that is relevant to current challenges and to increase uptake
Robert K. D. McLean, Fred Carden, Ian D. Graham, Alice B. Aiken, Rebecca Armstrong, Judy Bray, Christine E. Cassidy, Olivia Daub, Erica Di Ruggiero, Leslie A. Fierro, Michelle Gagnon, Alison M. Hutchinson, Roman Kislov, Anita Kothari, Sara Kreindler, Chris McCutcheon, Jessica Reszel, Gayle Scarrow   +17 more
doaj   +1 more source

Innovation and Integrity in Intervention Research: Conceptual Issues, Methodology, and Knowledge Translation [PDF]

Prevention Science, 2018
In this article, we introduce the special issue entitled Innovation and Integrity in Intervention Science. Its focus is on essential problems and prospects for intervention research examining two related topics, i.e., methodological issues and research integrity, and challenges in the transfer of research knowledge into practice and policy.
Tina, Malti, Andreas, Beelmann, Gil G, Noam, Simon, Sommer   +3 more
openaire   +2 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source