Results 51 to 60 of about 570,018 (263)

INTEGRATED MANAGEMENT SYSTEM FOR A SOCIETY FROM INDUSTRY OF MACHINERY AND EQUIPMENT [PDF]

Fiabilitate şi Durabilitate, 2014
In this paper shows the importance that it has SMI in a society of the industry of machinery and equipment. An integrated management system is the mode to design, implement and certify two or more management systems: Quality - Environment, Quality ...
Constanţa RĂDULESCU
doaj  

The Integrated Management System – A Transition Pathway to a Sustainable and Circular Bioeconomy [PDF]

Ovidius University Annals: Economic Sciences Series, 2020
Starting from the current context, characterized by global warming, limited non-renewable resources, ecosystem degradation and population growth, organizations around the world have become increasingly concerned with achieving the goal of sustainable ...
Valentina Irena Tudoran (Niculiță), Elena Condrea   +1 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Integration management system – new of requirements of ISO 9001:2015 and ISO 14001:2015 standards

Production Engineering Archives, 2016
Organizations are becoming more aware of the importance of integrated management systems (IMS). Interest in this subject indicates that IMS are seen as "management systems of the future“.
Renata Nováková, Katarína Čekanová, Alena Pauliková   +2 more
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Sistema Único Integrado de Gestión: Calidad, Ambiente, Seguridad y Salud

Teuken Bidikay, Revista Latinoamericana de Investigación en Organizaciones Ambiente y Sociedad, 2019
El artículo propone un Sistema Único Integrado (SUI) para fortalecer los sistemas de gestión ISO 9001, ISO 14001, OHSAS 18001 y Código ISM de cuatro unidades de negocio de un corporativo que opera en la industria petrolera marina en Méjico, en un entorno
Juan Froylán Cuadros Domínguez, Jesús Cuauhtémoc Téllez Gaytán   +1 more
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Overview of Integrated Vehicle Management System

Xibei Gongye Daxue Xuebao, 2020
Under the modern high-tech condition, the demand of air combat has been stricter on the combat performance and the integration of fighter, which impels the application of integrated vehicle management technology and makes it become the core technology of

doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Sustaining improvement of dispatcher-assisted cardiopulmonary resuscitation for out-of-hospital cardiac arrest patients in Japan: An observational study

Resuscitation Plus, 2020
Objectives: We aimed to estimate the relationship between the promotion of bystander cardiopulmonary resuscitation (CPR) with dispatcher-assistance over time and good cerebral function after out-of-hospital cardiac arrests (OHCAs).
R. Sagisaka, K. Nakagawa, M. Kayanuma, S. Tanaka, H. Takahashi, T. Komine, H. Tanaka   +6 more
doaj   +1 more source