Results 101 to 110 of about 2,496,190 (308)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Meso : prvi hrvatski časopis o mesu, 2009 U radu su opisane vojne norme u području upravljanja kvalitetom i sigurnošću kao jedan od sastavnih dijelova Integriranog sustava upravljanja (eng. Integrated Management System, IMS). Objedinjuje sustav upravljanja kvalitetom (ISO 9001), sustav upravljanja okolišem (ISO 14001), sustav upravljanja zdravljem i sigurnošću na radu (OHSAS 18001) i sustav ...
Zdolec, Nevijo +6 more
openaire
Integrated ADR Management System
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 2007 Recently, as the variety of medicines being used has increased, so has the incidence of adverse drug reactions (ADRs) and the range of different types of reactions experienced.It is thus important to determine causative medicines as soon as possible and prevent them being administered to patients again.With these objectives in mind, we established an ...
Katsuaki Honda +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Trudy Odesskogo Politehničeskogo Universiteta, 2015 This paper is devoted to research of the problems associated with uncertainty and incertitude in the risk assessment, which can take place in developing and implementing an integrated management system.
Morteza Rajab Zadeh +2 more
doaj +1 more source
Integrated Hospital Management System
Journal of Student Research, 2017 There are many private hospitals in Oman. Some of the hospitals are having their own web-based applications providing the details of services provided by the hospital and manage appointments done by the patients. However, there is no web-based application which provides a common integrated platform to compare services provided by various hospitals and ...
Maha Mohammed Al Habsi, Syed Ateeq Ahmed
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Integrated Management Systems as a Tool for Achieving Continuous Improvements in Performance
Littera Scripta, 2018 The paper presents an analysis of the factors that affect the performance, efficacyand efficiency of the implementation of integrated management systems in an organisation, as well as identifiesthe potential problems that might occur during ...
Marta Karkalíková, Rastislav Strhan
doaj