Results 81 to 90 of about 18,584,931 (274)

Safety Barriers Integrity Management System

Chemical Engineering Transactions, 2014
Since the beginning of 2010 Petrobras has been searching for a tool that could help it to manage the risk of all E&P (Exploration & Production) production installations. At the end of 2010 it has been decided to use the Bow-tie diagram tool to identify all the qualitative risk and manage it.
Felicio Pedro Costa Neto, Joao Luiz Ribeiro, Katia Lucia Ugulino, Sergio Marcos Mingrone   +3 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

AN INTEGRATED MULTIOBJECTIVE PORTFOLIO MANAGEMENT SYSTEM

Mathematical and Computer Modelling, 1989
The literature on portfolio management is rather abundant, with many valuable suggestions for improving the activity of large or small companies involved in the investment business. Few propositions, if any, are concerned with a full integrated system for helping portfolio managers in the considerable tasks of collecting information, making predictions
Colson, Gerard, De Bruyn, Christian
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Améliorer la productivité et la rentabilité de l'élevage bovin grâce à des stratégies agroécologiques issues de l'agriculture basée sur la culture de la noix de cajou dans le nord du Bénin

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux
Contexte : L'élevage bovin dans le nord du Bénin est de plus en plus contraint par la diminution des pâturages et la mauvaise qualité du fourrage, en particulier pendant la saison sèche.
Bernus Zinsou Djigbe, Saliou Adedigba, Rodrigue Vivien Cao Diogo   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Equity or exclusion? An alternative framework to disaster risks assessment metrics

Progress in Disaster Science
Existing disaster risk assessments often are not fully addressing the social, economic, and political factors that exacerbate vulnerabilities, leading to incomplete pictures of the situations of marginalized populations.
Jaziar Radianti
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Integrated Management Systems in Latvian Enterprises

Standards in different areas - quality, environment, occupational health and safety - are tools for deployment of sustainable development in any enterprise regardless of its size or sector of industry.
Mazais, Jānis, Mežinska, Iveta
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source