Results 81 to 90 of about 438,233 (262)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Meso : prvi hrvatski časopis o mesu, 2009 U radu su opisane vojne norme u području upravljanja kvalitetom i sigurnošću kao jedan od sastavnih dijelova Integriranog sustava upravljanja (eng. Integrated Management System, IMS). Objedinjuje sustav upravljanja kvalitetom (ISO 9001), sustav upravljanja okolišem (ISO 14001), sustav upravljanja zdravljem i sigurnošću na radu (OHSAS 18001) i sustav ...
Zdolec, Nevijo +6 more
openaire
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CoRRAvec l’évolution des approches processus au sein des organisations, l’importance croissante des systèmes de management de la qualité (comme l’ISO 9001) et l’introduction récente de l’ISO 30401 pour le management de la connaissance, nous examinons comment ces différents éléments convergent dans la perspective d’un Système de Management Intégré.
Prieur, Patrick, Belloni, Aline
openaire +3 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Development and Operationalization of a Model of Innovation Management System as Part of an Integrated Quality-Environment-Safety System [PDF]
Amfiteatru Economic, 2017 The results of the research, presented in this article, have the purpose to contribute in the area of innovation management and its relation to other management systems.
Dorin Maier +3 more
doaj
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Performance Measurement of Management System Standards Using the Balanced Scorecard [PDF]
Amfiteatru Economic, 2017 Management system standards (MSS), such as ISO standards, TQM, etc. are widely-used standards adopted by millions of organizations worldwide. It is still an unclear question whether these standards are beneficial for an organization, besides the fact ...
Jan Kopia +3 more
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source