Results 71 to 80 of about 18,584,931 (274)

Analysis of uncertainty and incertitude in the risk assessment when development and implementation of integrated management systems

Trudy Odesskogo Politehničeskogo Universiteta, 2014
This paper is devoted to research of the problems associated with uncertainty and incertitude in the risk assessment, which can take place in developing and implementing an integrated management system.
Раджаб Заде Мортеза, В.А. Залога, Н.В. Сущенко   +2 more
doaj   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional-Informational Factors Affecting Health System Integration

مدیریت اطلاعات سلامت, 2018
Introduction: Integration in the health system has many benefits for patients, providers, and the system itself. This research was conducted to determine the functional and informational variables affecting the integration of Iranian health system in ...
Bayaneh Seyedamini, Leila Riahi, Mahmoud Mahmoudi-Majdabadifarahani, Seyed Jamaleddin Tabibi, Iravan Masoudi-Asl   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Crop and Weather Report Nov. 9 [PDF]

, 2009
Crop and weather report guests include Iowa State University Extension climatologist Elwynn Taylor, integrated pest management specialist Rich Pope, and economist Chad Hart.
Integrated Crop Management News
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Highly Integrated and Mobile Sensor System for Dissolved Organic Matter in Stream Ecosystems

Proceedings, 2018
The impact of agricultural land use on the composition of dissolved organic matter (DOM) and its effects on the aquatic carbon cycle are still largely unknown.
Thomas Posnicek, Gabriele Weigelhofer, Alexander Eder, Martin Brandl   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Increasing the Efficiency and Quality of Educational Services: Improvement of Their Quality Management Systems with Complex Implementation of ISO Standards

Экономика и управление, 2019
This study is dedicated to the issues of improving the quality management systems (QMS) of educational organizations, and increasing the quality of their educational services, by complying with the requirements of various families of ISO standards ...
Tat’yana A. Borisova, Vladimir Ya. Dmitriev   +1 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source