Results 61 to 70 of about 433,699 (263)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Equity or exclusion? An alternative framework to disaster risks assessment metrics
Progress in Disaster ScienceExisting disaster risk assessments often are not fully addressing the social, economic, and political factors that exacerbate vulnerabilities, leading to incomplete pictures of the situations of marginalized populations.
Jaziar Radianti
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THE DEVELOPMENT DIRECTIONS OF MANAGEMENT INTEGRATED SYSTEMS
Дискурс, 2017 The main development directions of management integrated systems including the questions connected with application of international standards to the systems of management and quality organized on the principles of total quality management are considered.
V. P. Semenov
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Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Trudy Odesskogo Politehničeskogo Universiteta, 2014 This paper is devoted to research of the problems associated with uncertainty and incertitude in the risk assessment, which can take place in developing and implementing an integrated management system.
Раджаб Заде Мортеза +2 more
doaj
Revue d’Elevage et de Médecine Vétérinaire des Pays TropicauxContexte : L'élevage bovin dans le nord du Bénin est de plus en plus contraint par la diminution des pâturages et la mauvaise qualité du fourrage, en particulier pendant la saison sèche.
Bernus Zinsou Djigbe +2 more
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FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source