Results 251 to 260 of about 5,237,372 (315)

Organ-on-a-chip platforms for disease modeling and in vitro diagnostic applications. [PDF]

Front Bioeng Biotechnol
Hao P, Deng J, Xu J.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

From Models to Meaning: The Integrator Pharmacologist's Role in Advancing Health Equity Across the Drug Development Continuum. [PDF]

Clin Pharmacol Ther
Krishna R.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Animal models of allergic rhinitis: current progress and advances in traditional Chinese medicine syndrome models. [PDF]

Front Allergy
Yang C, Yee SS, Feng H, Zhao J.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Editorial: Evolving strategies in Lyme borreliosis treatment and prevention. [PDF]

Front Med (Lausanne)
Šmit R, Zhang Y.
europepmc   +1 more source

Organ-on-chip bridging musculoskeletal disease modeling and precision therapeutic discovery. [PDF]

Trends Biotechnol
Gao Q, Lee ML, Makarczyk M, Chow SK, Bunnell BA, Lin H, Goodman SB.   +6 more
europepmc   +1 more source

Biosensor applications in organ-on-a-chip platforms and disease modeling. [PDF]

Front Bioeng Biotechnol
Coln E, Miller C, Hickman JJ, Long CJ.
europepmc   +1 more source