Results 51 to 60 of about 5,237,372 (315)

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Detecting Cold Pool Family Trees in Convection Resolving Simulations

Journal of Advances in Modeling Earth Systems
Recent observations and modeling increasingly reveal the key role of cold pools in organizing the convective cloud field. Several methods for detecting cold pools in simulations exist, but are usually based on buoyancy fields and fall short of reliably ...
Jannik Hoeller, Romain Fiévet, Jan O. Haerter   +2 more
doaj   +1 more source

Integrating telemetry data into spatial capture–recapture modifies inferences on multi‐scale resource selection

Ecosphere, 2018
Estimating population size and resource selection functions (RSFs) are common approaches in applied ecology for addressing wildlife conservation and management objectives.
Daniel W. Linden, Alexej P. K. Sirén, Peter J. Pekins   +2 more
doaj   +1 more source

Integrability in sigma-models [PDF]

, 2019
Abstract The following topics are covered in this chapter: (1) Homogeneous spaces, (2) Classical integrability of sigma-models in two dimensions, (3) Topological terms, (4) Background-field method and beta-function, (5) S-matrix bootstrap in the O(N) model, (6) Supersymmetric coset models and strings on AdS(d) x X.
openaire   +2 more sources

Een inventariserend veldonderzoek door middel van boringen (IVO-O), karterende fase

, 2017
In maart 2016 is een verkennend booronderzoek uitgevoerd. Het onderzoek diende te resulteren in een onderverdeling van kansarme en kansrijke zones voor de aanwezigheid van archeologische vindplaatsen in het onderzoeksgebied.
Moor, dr. J.J.W. de (EARTH Integrated Archaeology B.V.)
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Tutorial on integrative spatiotemporal modeling by integrative modeling platform

Protein Science
AbstractCells function through dynamic interactions between macromolecules. Detailed characterization of the dynamics of large biomolecular systems is often not feasible by individual biophysical methods. In such cases, it may be possible to compute useful models by integrating multiple sources of information.
Andrew P. Latham, Miha Rožič, Benjamin M. Webb, Andrej Sali   +3 more
openaire   +3 more sources

Neural Integrator: A Sandpile Model [PDF]

Neural Computation, 2008
We investigated a model for the neural integrator based on hysteretic units connected by positive feedback. Hysteresis is assumed to emerge from the intrinsic properties of the cells. We consider the recurrent networks containing either bistable or multistable neurons. We apply our analysis to the oculomotor velocity-to-position neural integrator that
Maxim Nikitchenko, Alexei A. Koulakov
openaire   +4 more sources

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source