Results 141 to 150 of about 1,156,952 (310)

Further developments in the conflation of CFD and building simulation [PDF]

, 2001
To provide practitioners with the means to tackle problems related to poor indoor environments, building simulation and computational fluid dynamics can usefully be integrated within a single computational framework.
Beausoleil-Morrison, I., Clarke, J.A., Denev, J., Macdonald, I. A., Melikov, A., Stankov, P.   +5 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Investigating metabolic interactions in a microbial co-culture through integrated modelling and experiments. [PDF]

Comput Struct Biotechnol J, 2020
Ravikrishnan A, Blank LM, Srivastava S, Raman K.   +3 more
europepmc   +1 more source

A logical model of conceptual integrity in data integration

Journal of Research of the National Institute of Standards and Technology, 2003
Conceptual integrity is required for the result of data integration to be cohesive and sensible. Compromised conceptual integrity results in "semantic faults," which are commonly blamed for latent integration bugs. A logical model of conceptual integrity in data integration and a simple example application are presented. Unlike constructive models that
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modelling the Choice of Car Parks in Urban Areas and Managing the Demand for Parking. [PDF]

, 2008
Car parks are an essential piece of infrastructure associated with the road networks, yet commonly available traffic assignment models do not to explicitly integrate them into the modelling process. This research attempts to integrate the choice of car
Balijepalli, N.C., May, A.D., Shepherd, S.P.   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

E-book Integrated Video Tutoring with Symbolic Modelling Techniques to Increase the Self-control of Bullying Perpetrators

Bisma The Journal of Counseling
Bullying has become a worrying global issue with increasing prevalence in various countries. Bullying is increasing in the world, one of which is due to lack of self-control.
Dea Aulia, Firman
doaj   +1 more source